Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.43 |
| ▸ | HPGD | P15428 | 10/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.43 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5137349 | 0.93 | C5AR1 (0.43) | TSHRALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL650694 | 0.92 | TSHR (0.51) | TSHRALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL649161 | 0.85 | C5AR1 (0.47) | TSHRALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL5136516 | 0.85 | C5AR1 (0.43) | TSHRALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL5135312 | 0.85 | C5AR1 (0.46) | TSHRALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL5135685 | 0.85 | FAAH (0.52) | TSHRALDH1A1KDM4EHPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL648480 | 0.84 | C5AR1 (0.46) | TSHRALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL5137489 | 0.83 | C5AR1 (0.48) | TSHRALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL4774335 | 0.83 | C5AR1 (0.44) | TSHRALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL5074963 | 0.83 | C5AR1 (0.43) | TSHRALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |