Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 8/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.40 |
| ▸ | DRD2 | P14416 | 6/20 | 0.40 |
| ▸ | DRD3 | P35462 | 6/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 2/20 | 0.32 |
| ▸ | DRD4 | P21917 | 2/20 | 0.32 |
| ▸ | DRD5 | P21918 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5134818 | 0.94 | TSHR (0.39) | OPRK1OPRM1OPRD1DRD2DRD3 | |
| SCHEMBL5135184 | 0.91 | TSHR (0.38) | TSHRNR1H3C5AR1TLR7PDE4B | |
| SCHEMBL5136624 | 0.90 | TSHR (0.40) | TSHRNR1H3C5AR1BCHEPDE4B | |
| SCHEMBL5135939 | 0.87 | HSP90AA1 (0.38) | TSHRNR1H2NR1H3TLR7 | |
| SCHEMBL5136862 | 0.86 | C5AR1 (0.36) | TSHRC5AR1 | |
| SCHEMBL5134566 | 0.85 | TSHR (0.41) | OPRK1OPRD1TSHRNR1H3C5AR1 | |
| SCHEMBL5135309 | 0.85 | TLR7 (0.41) | TLR7 | |
| SCHEMBL5137324 | 0.85 | ACHE (0.36) | TSHRC5AR1BCHETLR7 | |
| SCHEMBL5137355 | 0.85 | TSHR (0.39) | TSHRNR1H3C5AR1TLR7PDE4B | |
| SCHEMBL5073855 | 0.85 | TSHR (0.36) | TSHRC5AR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |