Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPRA | P18433 | 1/20 | 0.38 |
| ▸ | PTPRB | P23467 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28297532 | 0.74 | CES1 (0.44) | KCNN4CES1PTPN2PTPN1PTPRA | |
| SCHEMBL27940396 | 0.72 | KCNN4 (0.43) | KCNN4SRCCES1PTPN2PTPN1 | |
| SCHEMBL8657016 | 0.71 | KCNN4 (0.64) | KCNN4SRCCES1PTPN2PTPN1 | |
| SCHEMBL5580542 | 0.71 | CES1 (0.69) | KCNN4SRCCES1MEN1OPRM1 | |
| SCHEMBL7186114 | 0.71 | KCNN4 (0.64) | KCNN4SRCCES1MEN1OPRM1 | |
| SCHEMBL2419456 | 0.71 | KCNN4 (0.64) | KCNN4SRCCES1PTPN2PTPN1 | |
| SCHEMBL2562200 | 0.71 | CES1 (0.40) | KCNN4CES1KMT2ATSHRMAPK1 | |
| SCHEMBL342555 | 0.71 | KCNN4 (0.64) | KCNN4SRCCES1MEN1OPRM1 | |
| SCHEMBL3174356 | 0.70 | KCNN4 (0.69) | KCNN4SRCCES1MEN1OPRM1 | |
| Triphenylacetic Acid Methyl Ester SCHEMBL7258414 | 0.70 | KCNN4 (1.00) | KCNN4SRCCES1MEN1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979355-A1 | SPIRO IMIDAZOLE DERIVATIVES AS PPAR MODULATORS | IRM LLC (BM) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007087448-A1 | SPIRO IMIDAZOLE DERIVATIVES AS PPAR MODULATORS | IRM LLC (BM) | 2007-08-02 | — | — | WO | disclosed |