Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.50 |
| ▸ | PDE4A | P27815 | 13/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.50 |
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5141139 | 0.84 | BRAF (0.71) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4911604 | 0.82 | BRAF (0.51) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4909057 | 0.80 | BRAF (0.49) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4907128 | 0.79 | BRAF (0.73) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4911610 | 0.75 | BRAF (0.41) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5135399 | 0.73 | BRAF (0.49) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14281773 | 0.71 | BRAF (0.63) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14281398 | 0.70 | BRAF (0.81) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4923252 | 0.67 | BRAF (1.00) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5809557 | 0.66 | BRAF (0.61) | BRAFIKBKBLIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984377-A2 | INHIBITORS OF TNF ALPHA , PDE4 AND B-RAF, COMPOSITIONS THEREOF AND METHODS OF USE THEREWITH | Signal Pharmaceuticals LLC (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007084560-A2 | INHIBITORS OF TNFα, PDE4 AND B-RAF, COMPOSITIONS THEREOF AND METHODS OF USE THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-07-26 | — | — | WO | disclosed |