Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.61 |
| ▸ | PIM1 | P11309 | 4/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.56 |
| ▸ | IKBKB | O14920 | 6/20 | 0.53 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | CDK8 | P49336 | 2/20 | 0.50 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CHUK | O15111 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | PRKACG | P22612 | 1/20 | 0.50 |
| ▸ | PRKACB | P22694 | 1/20 | 0.50 |
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5805575 | 0.88 | MAPT (0.61) | ABCC1ABCG2IKBKBLIMK1MAPT | |
| SCHEMBL6111409 | 0.84 | IKBKB (0.64) | BRAFPIM1KDRIKBKBLIMK1 | |
| SCHEMBL6112158 | 0.84 | MAPT (0.55) | IKBKBLIMK1MAPTCDK8CDK19 | |
| SCHEMBL1321257 | 0.83 | PIM1 (0.65) | BRAFPIM1KDRIKBKBLIMK1 | |
| SCHEMBL6111488 | 0.82 | EEF2K (0.59) | IKBKBLIMK1MAPTMEN1KMT2A | |
| SCHEMBL6109707 | 0.82 | MAPT (0.56) | BRAFPIM1IKBKBLIMK1MAPT | |
| SCHEMBL6110090 | 0.82 | IKBKB (0.65) | BRAFIKBKBLIMK1MAPTMEN1 | |
| SCHEMBL6110291 | 0.82 | KMT2A (0.71) | IKBKBLIMK1MAPTMEN1KMT2A | |
| SCHEMBL13186380 | 0.81 | BRAF (0.77) | BRAFPIM1KDRABCC1ABCG2 | |
| SCHEMBL6110854 | 0.81 | MAPT (0.63) | IKBKBLIMK1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006100095-A1 | SUBSTITUTED CARBOXAMIDES METHOD FOR PRODUCTION AND USE THEREOF AS TNF-ALPHA RELEASE INHIBITORS | CURACYTE DISCOVERY GMBH (DE) | 2006-09-28 | — | — | WO | claimed |