Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 5/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.36 |
| ▸ | ADH1B | P00325 | 1/20 | 0.35 |
| ▸ | ADH1C | P00326 | 1/20 | 0.35 |
| ▸ | ADH1A | P07327 | 1/20 | 0.35 |
| ▸ | ADH4 | P08319 | 1/20 | 0.35 |
| ▸ | ADH7 | P40394 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28813965 | 0.93 | OPRM1 (0.50) | OPRM1FAAHCNR1CNR2SPHK1 | |
| SCHEMBL5538153 | 0.93 | OPRM1 (0.50) | OPRM1FAAHCNR1CNR2SPHK1 | |
| SCHEMBL15380779 | 0.93 | OPRM1 (0.50) | OPRM1FAAHCNR1CNR2SPHK1 | |
| SCHEMBL3316528 | 0.93 | OPRM1 (0.50) | OPRM1FAAHCNR1CNR2SPHK1 | |
| SCHEMBL6425397 | 0.93 | OPRM1 (0.50) | OPRM1FAAHCNR1CNR2SPHK1 | |
| SCHEMBL24090459 | 0.93 | OPRM1 (0.50) | OPRM1FAAHCNR1CNR2SPHK1 | |
| SCHEMBL471924 | 0.93 | OPRM1 (0.50) | OPRM1FAAHCNR1CNR2SPHK1 | |
| SCHEMBL3317092 | 0.93 | OPRM1 (0.50) | OPRM1FAAHCNR1CNR2SPHK1 | |
| SCHEMBL22649557 | 0.93 | OPRM1 (0.50) | OPRM1FAAHCNR1CNR2SPHK1 | |
| SCHEMBL18106104 | 0.91 | OPRM1 (0.52) | OPRM1FAAHCNR1CNR2SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1007033-B1 | LYMPHOCYTE FUNCTION ANTIGEN-1 ANTAGONISTS | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | disclosed |
| US-6630492-B1 | Lymphocyte function antigen-1 antagonists | NOVARTIS AG (CH) | 2003-10-07 | — | — | US | disclosed |
| EP-1007033-A1 | LYMPHOCYTE FUNCTION ANTIGEN-1 ANTAGONISTS | Novartis AG (CH) | 2000-06-14 | — | — | EP | disclosed |
| WO-1999011258-A1 | LYMPHOCYTE FUNCTION ANTIGEN-1 ANTAGONISTS | NOVARTIS AG (CH) | 1999-03-11 | — | — | WO | disclosed |