Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.38 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | ATP4A | P20648 | 2/20 | 0.34 |
| ▸ | ATP4B | P51164 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5136254 | 0.92 | C5AR1 (0.39) | C5AR1CASRBCL2L2HTR1AHTR2C | |
| SCHEMBL650283 | 0.90 | C5AR1 (0.42) | CRHR1C5AR1ATP4AATP4BDRD2 | |
| SCHEMBL5137495 | 0.89 | ATP4A (0.39) | CRHR1C5AR1PDE2AATP4AATP4B | |
| SCHEMBL5136974 | 0.88 | ATP4A (0.39) | CRHR1C5AR1ATP4AATP4BDRD2 | |
| SCHEMBL5138077 | 0.88 | C5AR1 (0.39) | CRHR1C5AR1CASRBCL2L2HTR1A | |
| SCHEMBL650201 | 0.87 | C5AR1 (0.41) | CRHR1C5AR1ATP4AATP4BDRD2 | |
| SCHEMBL648163 | 0.87 | C5AR1 (0.41) | CRHR1C5AR1ATP4AATP4BDRD2 | |
| SCHEMBL652364 | 0.87 | C5AR1 (0.41) | CRHR1C5AR1ATP4AATP4BDRD2 | |
| SCHEMBL649935 | 0.87 | C5AR1 (0.41) | CRHR1C5AR1ATP4AATP4BDRD2 | |
| SCHEMBL652236 | 0.86 | C5AR1 (0.42) | CRHR1C5AR1ATP4AATP4BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |