Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.41 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | CASP1 | P29466 | 4/20 | 0.39 |
| ▸ | CASP7 | P55210 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5135705 | 0.95 | CALM1 (0.45) | C5AR1CALM1CAMKK2TLR7TSHR | |
| SCHEMBL5170566 | 0.94 | CALM1 (0.43) | C5AR1CALM1CAMKK2TLR7ALDH1A1 | |
| SCHEMBL5135794 | 0.93 | TSHR (0.42) | POLBC5AR1ALDH1A1HSD17B10LMNA | |
| SCHEMBL5134931 | 0.92 | CALM1 (0.44) | C5AR1CALM1CAMKK2TLR7ALDH1A1 | |
| SCHEMBL5072289 | 0.92 | ABCB1 (0.42) | C5AR1CALM1CAMKK2TLR7USP2 | |
| SCHEMBL5137491 | 0.91 | CALM1 (0.45) | C5AR1CALM1CAMKK2TLR7USP2 | |
| SCHEMBL5074293 | 0.91 | CALM1 (0.45) | C5AR1CALM1CAMKK2TLR7USP2 | |
| SCHEMBL5135329 | 0.91 | TP53 (0.46) | C5AR1ALDH1A1HSD17B10LMNATP53 | |
| SCHEMBL5167256 | 0.90 | C5AR1 (0.44) | C5AR1TLR7ALDH1A1TSHRCRHR1 | |
| SCHEMBL5137893 | 0.90 | C5AR1 (0.43) | C5AR1TP53TSHRCRHR1TSPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |