Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.76 |
| ▸ | KDR | P35968 | 20/20 | 0.76 |
| ▸ | AURKA | O14965 | 1/20 | 0.69 |
| ▸ | FPR1 | P21462 | 1/20 | 0.69 |
| ▸ | FPR3 | P25089 | 1/20 | 0.69 |
| ▸ | GPR183 | P32249 | 1/20 | 0.69 |
| ▸ | SMO | Q99835 | 1/20 | 0.69 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14535232 | 0.93 | MET (0.75) | METKDRAURKAFPR1FPR3 | |
| SCHEMBL3567646 | 0.92 | MET (0.76) | METKDRAURKAFPR1FPR3 | |
| SCHEMBL3559949 | 0.92 | MET (0.74) | METKDRAURKAFPR1FPR3 | |
| SCHEMBL3559332 | 0.91 | MET (0.78) | METKDRAURKAFPR1FPR3 | |
| SCHEMBL3559953 | 0.88 | MET (0.75) | METKDRAURKAFPR1FPR3 | |
| SCHEMBL13166667 | 0.87 | MET (0.81) | METKDRAURKAFPR1FPR3 | |
| SCHEMBL3573942 | 0.86 | MET (1.00) | METKDR | |
| SCHEMBL3566419 | 0.86 | MET (0.79) | METKDRAURKAFPR1FPR3 | |
| SCHEMBL3569993 | 0.86 | MET (0.89) | METKDR | |
| SCHEMBL13185318 | 0.86 | MET (0.79) | METKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904504-A2 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | Methylgene, Inc. (CA) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007054831-A2 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | METHYLGENE, INC. (CA) | 2007-05-18 | — | — | WO | disclosed |