Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.31 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4659869 | 0.84 | CYP17A1 (0.38) | CFTR | |
| SCHEMBL2768751 | 0.72 | CFTR (0.33) | CFTR | |
| SCHEMBL14783863 | 0.68 | CFTR (0.50) | CFTRTSHRMAPTKMT2AMEN1 | |
| SCHEMBL6430612 | 0.65 | LCK (0.45) | TSHRLMNAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL16164495 | 0.65 | PIK3CA (0.44) | KMT2AMEN1PIK3CAKCNQ3KCNQ2 | |
| SCHEMBL16703963 | 0.65 | POLQ (0.42) | LMNAMAPTKMT2AMEN1PIK3CA | |
| SCHEMBL22831934 | 0.64 | MEN1 (0.41) | TSHRLMNAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL14472219 | 0.64 | SMN1; SMN2 (0.45) | MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL6117196 | 0.64 | HTT (0.45) | TSHRLMNAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL8699897 | 0.64 | GAA (0.41) | TSHRMAPTSMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963324-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007071936-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2007-06-28 | — | — | WO | disclosed |