Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.62 |
| ▸ | NCF1 | P14598 | 1/20 | 0.60 |
| ▸ | ACP1 | P24666 | 3/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | USP1 | O94782 | 1/20 | 0.47 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL213444 | 0.90 | APP (0.62) | APPNCF1ACP1EGFRPOLB | |
| SCHEMBL210947 | 0.78 | EGFR (0.78) | APPNCF1ACP1EGFRPOLB | |
| SCHEMBL13968056 | 0.76 | KMT2A (0.66) | APPPOLBLMNAMAPTKMT2A | |
| SCHEMBL2256525 | 0.76 | APP (1.00) | APPNCF1EGFRPOLBNR2F2 | |
| SCHEMBL1685041 | 0.76 | APP (0.74) | APPNCF1ACP1EGFRPOLB | |
| SCHEMBL28802725 | 0.75 | POLB (0.47) | APPNCF1ACP1EGFRPOLB | |
| SCHEMBL21796420 | 0.75 | NCF1 (0.59) | APPNCF1ACP1EGFRPOLB | |
| Hydrochloric Acid SCHEMBL1685081 | 0.75 | APP (0.72) | APPNCF1ACP1EGFRPOLB | |
| SCHEMBL26981105 | 0.75 | EGFR (0.60) | APPNCF1ACP1EGFRPOLB | |
| SCHEMBL28487139 | 0.73 | EGFR (0.56) | APPNCF1ACP1EGFRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948173-A2 | HYDROXY AND ALKOXY SUBSTITUTED 1H-IMIDAZOQUINOLINES AND METHODS | Coley Pharmaceutical Group, Inc. (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007056112-A2 | HYDROXY AND ALKOXY SUBSTITUTED 1H-IMIDAZOQUINOLINES AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2007-05-18 | — | — | WO | disclosed |