Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 12/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 11/20 | 0.56 |
| ▸ | PDE10A | Q9Y233 | 10/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.53 |
| ▸ | AXL | P30530 | 2/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4975720 | 0.92 | PDGFRB (0.56) | PDE3APDE3BPDE10APDGFRAKIT | |
| SCHEMBL14599422 | 0.87 | PDGFRB (0.63) | PDE3APDE3BPDGFRAKITPDGFRB | |
| SCHEMBL4965967 | 0.86 | PDE3B (0.64) | PDE3APDE3BPDE10APDGFRB | |
| SCHEMBL4968219 | 0.84 | PDGFRB (0.59) | PDE3APDE3BPDE10APDGFRAKIT | |
| SCHEMBL27732085 | 0.83 | PDGFRB (0.60) | PDE3APDE3BPDE10APDGFRAKIT | |
| SCHEMBL4965715 | 0.82 | PDGFRA (0.60) | PDE3APDE3BPDE10APDGFRAKIT | |
| SCHEMBL4974993 | 0.80 | PDGFRA (0.64) | PDE3APDE3BPDE10APDGFRAKIT | |
| SCHEMBL5824504 | 0.80 | KDR (0.74) | PDGFRAKITPDGFRBKDR | |
| SCHEMBL5825054 | 0.79 | KDR (0.73) | PDGFRAKITPDGFRBKDR | |
| SCHEMBL5824888 | 0.79 | KDR (0.73) | PDGFRAKITPDGFRBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893206-A2 | SYNERGISTIC MODULATION OF FLT3 KINASE USING AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-05 | — | — | EP | disclosed |
| US-20070004763-A1 | AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-01-04 | — | — | US | disclosed |
| US-20070004763-A1 | AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-01-04 | — | — | US | disclosed |
| US-20070004763-A1 | AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-01-04 | — | — | US | disclosed |
| WO-2006135636-A2 | SYNERGISTIC MODULATION OF FLT3 KINASE USING AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-21 | — | — | WO | disclosed |
| US-20060281771-A1 | SYNERGISTIC MODULATION OF FLT3 KINASE USING AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281771-A1 | SYNERGISTIC MODULATION OF FLT3 KINASE USING AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | FLT3, CDC42BPG, PRKCQ | PDE3A 3303/4885PDE3B 2347/4885PDE10A 4119/4885 |
| US-20070004763-A1 | AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | FLT3, BMX, ABL1 | PDE3A 1892/4885PDE3B 1450/4885PDE10A 2325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.