Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.44 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.40 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5135433 | 0.95 | C5AR1 (0.46) | C5AR1CALM1CAMKK2CNR2TLR7 | |
| SCHEMBL648419 | 0.94 | C5AR1 (0.46) | C5AR1CALM1CAMKK2CNR2TLR7 | |
| SCHEMBL5147943 | 0.92 | C5AR1 (0.43) | C5AR1CNR2HSP90AA1HSP90AB1SMN1; SMN2 | |
| SCHEMBL5136578 | 0.92 | C5AR1 (0.43) | C5AR1CNR2SMN1; SMN2MAPTTSHR | |
| SCHEMBL5135383 | 0.90 | C5AR1 (0.45) | C5AR1CALM1CAMKK2CNR2TLR7 | |
| SCHEMBL5136482 | 0.90 | C5AR1 (0.47) | C5AR1SMN1; SMN2NR1H3TSHRHSD17B10 | |
| SCHEMBL5136530 | 0.89 | C5AR1 (0.41) | C5AR1CNR2TLR7MEN1KMT2A | |
| SCHEMBL5135705 | 0.89 | CALM1 (0.45) | C5AR1CALM1CAMKK2CNR2TLR7 | |
| SCHEMBL5137491 | 0.89 | CALM1 (0.45) | C5AR1CALM1CAMKK2CNR2TLR7 | |
| SCHEMBL652044 | 0.89 | C5AR1 (0.43) | C5AR1CALM1CAMKK2TLR7HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |