Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 11/20 | 0.70 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.47 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1590176 | 0.87 | P2RX7 (0.79) | P2RX7KCNQ2KDM4EALDH1A1 | |
| SCHEMBL1590347 | 0.87 | P2RX7 (0.76) | P2RX7KCNQ2KDM4E | |
| SCHEMBL1590173 | 0.87 | P2RX7 (0.79) | P2RX7KCNQ2KDM4EALDH1A1 | |
| SCHEMBL1590848 | 0.87 | P2RX7 (0.76) | P2RX7KCNQ2KDM4E | |
| SCHEMBL1592023 | 0.87 | P2RX7 (0.79) | P2RX7KCNQ2KDM4EALDH1A1 | |
| SCHEMBL1590419 | 0.86 | P2RX7 (0.67) | P2RX7KCNQ2ALDH1A1POLB | |
| SCHEMBL1590495 | 0.85 | P2RX7 (0.80) | P2RX7KCNQ2PARP14KDM4EALDH1A1 | |
| SCHEMBL1591221 | 0.85 | P2RX7 (0.80) | P2RX7KCNQ2PARP14KDM4EALDH1A1 | |
| SCHEMBL1591210 | 0.85 | P2RX7 (0.80) | P2RX7KCNQ2PARP14KDM4EALDH1A1 | |
| SCHEMBL1590379 | 0.85 | P2RX7 (0.79) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1933622-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | Renovis, Inc. (US) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007109192-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2007-09-27 | — | — | WO | disclosed |