Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SGK1 | O00141 | 3/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL411808 | 0.81 | PDPK1 (0.41) | PDPK1AAK1NEK1GSK3AGSK3B | |
| SCHEMBL10260007 | 0.75 | RIPK1 (0.44) | PDPK1AAK1NEK1GSK3AGSK3B | |
| SCHEMBL858397 | 0.74 | PDPK1 (0.43) | PDPK1AAK1NEK1MEN1KMT2A | |
| SCHEMBL5137998 | 0.73 | PDPK1 (0.39) | PDPK1AAK1NEK1MEN1KMT2A | |
| SCHEMBL859366 | 0.72 | CYP11B1 (0.44) | PDPK1AAK1NEK1MEN1KMT2A | |
| SCHEMBL413921 | 0.72 | PDPK1 (0.42) | PDPK1AAK1NEK1GSK3AGSK3B | |
| SCHEMBL416336 | 0.72 | PDPK1 (0.42) | PDPK1AAK1NEK1GSK3AGSK3B | |
| SCHEMBL859111 | 0.71 | KIT (0.50) | PDPK1AAK1NEK1PIK3CACCNT1 | |
| SCHEMBL859347 | 0.71 | BRD4 (0.43) | PDPK1AAK1NEK1MEN1KMT2A | |
| Butyramide SCHEMBL28770471 | 0.71 | PDPK1 (0.41) | PDPK1AAK1NEK1GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893612-A1 | PYRROLO [2, 3-B]PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2007002433-A1 | PYRROLO [2, 3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2007-01-04 | — | — | WO | disclosed |