Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 11/20 | 1.00 |
| ▸ | DRD5 | P21918 | 4/20 | 0.61 |
| ▸ | DRD2 | P14416 | 3/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | THPO | P40225 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.60 |
| ▸ | GPR183 | P32249 | 1/20 | 0.60 |
| ▸ | APLNR | P35414 | 1/20 | 0.60 |
| ▸ | GLP1R | P43220 | 1/20 | 0.60 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29507713 | 1.00 | DRD1 (1.00) | DRD1DRD5DRD2CYP1A2CYP2D6 | |
| SCHEMBL29602922 | 1.00 | DRD1 (1.00) | DRD1DRD5DRD2CYP1A2CYP2D6 | |
| SCHEMBL10690816 | 0.88 | DRD1 (0.79) | DRD1DRD5DRD2CYP1A2CYP2D6 | |
| SCHEMBL10691047 | 0.86 | DRD1 (0.75) | DRD1DRD5DRD2CYP1A2CYP2D6 | |
| SCHEMBL10690780 | 0.83 | DRD1 (0.73) | DRD1DRD5DRD2CYP1A2CYP2D6 | |
| Bromide SCHEMBL10691009 | 0.82 | DRD1 (0.72) | DRD1DRD5DRD2CYP1A2CYP2D6 | |
| SCHEMBL9404246 | 0.82 | DRD1 (0.69) | DRD1DRD5DRD2CYP1A2CYP2D6 | |
| SCHEMBL9529544 | 0.81 | DRD1 (0.68) | DRD1DRD5DRD2CYP1A2CYP2D6 | |
| SCHEMBL5138044 | 0.81 | DRD1 (0.68) | DRD1DRD5DRD2CYP1A2CYP2D6 | |
| SCHEMBL9529162 | 0.80 | DRD1 (0.65) | DRD1DRD5DRD2CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080096926-A1 | Treatment Of Cognitive Impairment Using A Selective Dopamine D1 Receptor Agonist | DRUGABUSE SCIENCES SAS (FR) | 2008-04-24 | — | — | US | disclosed |
| EP-1011679-B1 | USE OF 8-NITRO-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES FOR THE MANUFACTURE OF A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF SLEEP DISORDERS | ADDEX PHARMACEUTICALS SA (CH) | 2003-07-30 | — | — | EP | disclosed |
| US-6211173-B1 | Use of 2,3,4,5-tetrahydro-1H-3-benzazepines for the manufacture of a pharmaceutical composition for the treatment of sleep disorders | CENES LIMITED (GB) | 2001-04-03 | — | — | US | disclosed |
| EP-1011679-A1 | USE OF 2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES FOR THE MANUFACTURE OF A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF SLEEP DISORDERS | CeNes Limited (GB) | 2000-06-28 | — | — | EP | disclosed |
| WO-1998040072-A1 | USE OF 2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES FOR THE MANUFACTURE OF A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF SLEEP DISORDERS | CENES LIMITED (GB) | 1998-09-17 | — | — | WO | disclosed |
| EP-0383247-B1 | Benzazepines with antidopaminergic activity | NOVO NORDISK AS (DK) | 1994-08-03 | — | — | EP | disclosed |
| EP-0347672-B1 | Benzazepine derivatives | NOVO NORDISK AS (DK) | 1994-03-02 | — | — | EP | disclosed |
| EP-0331130-B1 | CARBAMIC ACID ESTER OF SUBSTITUTED 7-HYDROXY-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES | NOVO NORDISK A/S (DK) | 1993-09-29 | — | — | EP | disclosed |
| US-5079243-A | Nervous System Disorders, Antidopaminergic Effect | NOVO NORDISK A/S (DK) | 1992-01-07 | — | — | US | disclosed |
| US-5025009-A | Treatment of central nervous system disorders; bioavailability | NOVO NORDISK A/S (DK) | 1991-06-18 | — | — | US | disclosed |
| US-5017571-A | Prodrugs, mental disorders | NOVO NORDISK A/S (DK) | 1991-05-21 | — | — | US | disclosed |
| US-5010074-A | Treating CNS disorders; dopamine antagonist; bioavailability | NOVO NORDISK A/S (DK) | 1991-04-23 | — | — | US | disclosed |
| EP-0383247-A1 | Benzazepines with antidopaminergic activity | NOVO NORDISK A/S (DK) | 1990-08-22 | — | — | EP | disclosed |
| EP-0331130-A1 | Carbamic acid ester of substituted 7-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepines | NOVO NORDISK A/S (DK) | 1989-09-06 | — | — | EP | disclosed |
| US-4751222-A | 2,3,4,5-tetrahydro-1H-3-benzazepines and CNS affecting use thereof | NOVO INDUSTRI A/S (DK) | 1988-06-14 | — | — | US | disclosed |
| EP-0200455-A2 | 2,3,4,5-tetrahydro-1H-3-benzazepines substituted in position 5 | NOVO NORDISK A/S (DK) | 1986-11-05 | — | — | EP | disclosed |