Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 11/20 | 0.69 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | DRD5 | P21918 | 5/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | GPR183 | P32249 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10691047 | 0.90 | DRD1 (0.75) | DRD1SLC6A2SLC6A4SLC6A3DRD5 | |
| SCHEMBL9404247 | 0.84 | DRD1 (0.47) | DRD1DRD5CYP2D6CYP3A4CYP1A2 | |
| SCHEMBL29602922 | 0.82 | DRD1 (1.00) | DRD1SLC6A2SLC6A4SLC6A3DRD5 | |
| SCHEMBL5138043 | 0.82 | DRD1 (1.00) | DRD1SLC6A2SLC6A4SLC6A3DRD5 | |
| SCHEMBL29507713 | 0.82 | DRD1 (1.00) | DRD1SLC6A2SLC6A4SLC6A3DRD5 | |
| SCHEMBL9529544 | 0.81 | DRD1 (0.68) | DRD1SLC6A2SLC6A4SLC6A3DRD5 | |
| SCHEMBL9529675 | 0.81 | DRD1 (0.65) | DRD1SLC6A2SLC6A4SLC6A3DRD5 | |
| SCHEMBL9404228 | 0.81 | DRD1 (0.46) | DRD1DRD5CYP2D6CYP3A4CYP1A2 | |
| SCHEMBL9529162 | 0.79 | DRD1 (0.65) | DRD1SLC6A2SLC6A4SLC6A3DRD5 | |
| SCHEMBL9530499 | 0.79 | DRD1 (0.62) | DRD1SLC6A2SLC6A4SLC6A3DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0383247-B1 | Benzazepines with antidopaminergic activity | NOVO NORDISK AS (DK) | 1994-08-03 | — | — | EP | claimed |
| US-5079243-A | Nervous System Disorders, Antidopaminergic Effect | NOVO NORDISK A/S (DK) | 1992-01-07 | — | — | US | claimed |
| EP-0383247-A1 | Benzazepines with antidopaminergic activity | NOVO NORDISK A/S (DK) | 1990-08-22 | — | — | EP | claimed |
| EP-0383247-B1 | Benzazepines with antidopaminergic activity | NOVO NORDISK AS (DK) | 1994-08-03 | — | — | EP | disclosed |
| US-5079243-A | Nervous System Disorders, Antidopaminergic Effect | NOVO NORDISK A/S (DK) | 1992-01-07 | — | — | US | disclosed |
| EP-0383247-A1 | Benzazepines with antidopaminergic activity | NOVO NORDISK A/S (DK) | 1990-08-22 | — | — | EP | disclosed |