Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 17/20 | 0.53 |
| ▸ | IGF1R | P08069 | 3/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL399573 | 0.84 | TNK2 (0.76) | TNK2IGF1RINSR | |
| SCHEMBL5138490 | 0.83 | TNK2 (0.45) | TNK2IGF1RINSR | |
| SCHEMBL398950 | 0.76 | TNK2 (0.76) | TNK2IGF1R | |
| SCHEMBL401942 | 0.74 | TNK2 (0.74) | TNK2IGF1RINSR | |
| SCHEMBL5141560 | 0.71 | IGF1R (0.47) | TNK2IGF1RINSR | |
| SCHEMBL399626 | 0.71 | TNK2 (0.64) | TNK2IGF1RINSR | |
| SCHEMBL5082715 | 0.71 | FLT3 (0.42) | TNK2INSR | |
| Carbamic Acid SCHEMBL4062520 | 0.70 | IGF1R (0.65) | TNK2IGF1RINSR | |
| SCHEMBL400022 | 0.70 | IGF1R (0.81) | TNK2IGF1RINSR | |
| SCHEMBL5141558 | 0.69 | IGF1R (0.57) | TNK2IGF1RINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979002-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI Pharmaceuticals, Inc. (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |
| WO-2007075554-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |