Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 13/20 | 0.45 |
| ▸ | IGF1R | P08069 | 7/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | INSR | P06213 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL400283 | 0.84 | TNK2 (0.66) | TNK2IGF1RCYP3A4INSR | |
| SCHEMBL5138353 | 0.83 | TNK2 (0.53) | TNK2IGF1RINSR | |
| SCHEMBL5085578 | 0.72 | IGF1R (0.55) | TNK2IGF1RCYP3A4INSR | |
| SCHEMBL5078959 | 0.71 | LCK (0.36) | TNK2IGF1RCYP3A4INSR | |
| SCHEMBL1683109 | 0.71 | IGF1R (0.71) | TNK2IGF1RCYP3A4INSR | |
| SCHEMBL397065 | 0.70 | IGF1R (0.57) | TNK2IGF1RCYP3A4INSR | |
| SCHEMBL401288 | 0.70 | IGF1R (0.73) | TNK2IGF1RCYP3A4INSR | |
| SCHEMBL400580 | 0.69 | IGF1R (0.59) | TNK2IGF1RINSR | |
| SCHEMBL400390 | 0.69 | BTK (0.52) | — | |
| SCHEMBL5189617 | 0.68 | IGF1R (0.47) | TNK2IGF1RCYP3A4INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |