Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP1 | P29972 | 3/20 | 1.00 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4232178 | 0.91 | AQP1 (0.83) | AQP1EZH2HRH4HRH3MAPK1 | |
| SCHEMBL4219176 | 0.89 | AQP1 (0.80) | AQP1EZH2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14112699 | 0.89 | AQP1 (0.80) | AQP1EZH2NPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4622016 | 0.88 | AQP1 (0.78) | AQP1EZH2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4224838 | 0.87 | AQP1 (0.79) | AQP1EZH2TP53CYP2C19 | |
| SCHEMBL4225189 | 0.87 | AQP1 (0.77) | AQP1EZH2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4224840 | 0.87 | AQP1 (0.79) | AQP1EZH2TP53CYP2C19 | |
| SCHEMBL4220698 | 0.84 | AQP1 (0.73) | AQP1EZH2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4226215 | 0.84 | AQP1 (1.00) | AQP1EZH2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4596131 | 0.83 | AQP1 (0.71) | AQP1EZH2NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007509174-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | claimed |
| EP-1998764-A2 | METHODS FOR TREATING COGNITIVE AND OTHER DISORDERS | Wyeth a Corporation of the State of Delaware (US) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007112065-A2 | METHODS FOR TREATING COGNITIVE AND OTHER DISORDERS | WYETH (US) | 2007-10-04 | — | — | WO | disclosed |