Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 9/20 | 0.36 |
| ▸ | EGFR | P00533 | 8/20 | 0.36 |
| ▸ | ABL1 | P00519 | 7/20 | 0.36 |
| ▸ | ABL2 | P42684 | 7/20 | 0.36 |
| ▸ | KDR | P35968 | 5/20 | 0.36 |
| ▸ | CDK1 | P06493 | 4/20 | 0.36 |
| ▸ | IGF1R | P08069 | 6/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | INSR | P06213 | 2/20 | 0.31 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | LATS1 | O95835 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL399404 | 0.88 | SRC (0.51) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL397596 | 0.78 | SRC (0.43) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL5138765 | 0.77 | SRC (0.53) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL5137561 | 0.76 | TP53 (0.41) | SRCEGFRTP53LMNAMAPT | |
| SCHEMBL398363 | 0.75 | SRC (0.68) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL400111 | 0.75 | SRC (0.46) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL399678 | 0.74 | SRC (0.49) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL401232 | 0.74 | SRC (0.40) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL402145 | 0.73 | SRC (0.45) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL400407 | 0.73 | SRC (0.48) | SRCEGFRABL1ABL2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |