Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 2/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6072771 | 0.84 | ADORA2A (0.56) | CDK5DYRK1ALMNACDK5R1ADORA2A | |
| SCHEMBL7011406 | 0.75 | ADORA2A (0.70) | CDK5DYRK1ALMNACDK5R1ADORA2A | |
| SCHEMBL4436700 | 0.74 | ADORA2A (0.60) | CDK5DYRK1ALMNACDK5R1ADORA2A | |
| SCHEMBL6072337 | 0.74 | CDK5 (0.54) | CDK5DYRK1ALMNACDK5R1ADORA2A | |
| SCHEMBL27886231 | 0.73 | ADORA2A (0.51) | CDK5DYRK1ALMNACDK5R1ADORA2A | |
| SCHEMBL6072052 | 0.73 | CDK5 (0.50) | CDK5DYRK1ALMNACDK5R1ADORA2A | |
| SCHEMBL27709601 | 0.73 | ADORA2A (0.49) | CDK5DYRK1ALMNACDK5R1ADORA2A | |
| SCHEMBL6072090 | 0.71 | ADORA2A (0.56) | ADORA2AHSD17B10ADRA2AHTTKDM4E | |
| SCHEMBL245321 | 0.71 | ADORA2A (0.60) | CDK5DYRK1ALMNACDK5R1ADORA2A | |
| SCHEMBL5139695 | 0.71 | KDM4E (0.52) | LMNAADORA2AHSD17B10ADRA2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432279-B2 | 4,6-diamino-[1,7]naphthyridine-3-carbonitrile inhibitors of Tpl2 kinase and methods of making and using the same | WYETH (US) | 2008-10-07 | — | — | US | disclosed |