Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 9/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6072337 | 0.84 | CDK5 (0.54) | ADORA2AHSD17B10ADRA2AHTTCDK5 | |
| SCHEMBL5138973 | 0.84 | CDK5 (0.51) | ADORA2AHSD17B10ADRA2AHTTCDK5 | |
| SCHEMBL6072052 | 0.83 | CDK5 (0.50) | ADORA2AHSD17B10ADRA2AHTTCDK5 | |
| SCHEMBL4436700 | 0.79 | ADORA2A (0.60) | ADORA2AHSD17B10ADRA2AHTTCDK5 | |
| SCHEMBL6072033 | 0.79 | CDK5 (0.49) | ADORA2AHSD17B10ADRA2AHTTCDK5 | |
| SCHEMBL6071938 | 0.78 | KDM4E (0.50) | ADORA2AHSD17B10HTTCDK5DYRK1A | |
| SCHEMBL7011406 | 0.77 | ADORA2A (0.70) | ADORA2AHSD17B10ADRA2AHTTCDK5 | |
| SCHEMBL6072774 | 0.76 | ALDH1A1 (0.54) | ADORA2AHSD17B10ADRA2AHTTKDM4E | |
| SCHEMBL6072090 | 0.76 | ADORA2A (0.56) | ADORA2AHSD17B10ADRA2AHTTKDM4E | |
| SCHEMBL27709601 | 0.75 | ADORA2A (0.49) | ADORA2AHSD17B10ADRA2AHTTCDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | WYETH (US) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | TNNI3K, CSNK1A1L, CDKL1 | ADORA2A 2729/4885HSD17B10 4176/4885ADRA2A 3607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.