Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 8/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.39 |
| ▸ | CASP1 | P29466 | 7/20 | 0.39 |
| ▸ | CASP7 | P55210 | 7/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 5/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5086449 | 0.87 | CYP1A2 (0.36) | CYP1A2ALDH1A1CYP3A4CYP2C9HSD17B10 | |
| SCHEMBL397895 | 0.87 | PIK3CD (0.43) | EGFRERBB2IGF1RPIK3CDPIK3CA | |
| SCHEMBL5139324 | 0.83 | ALDH1A1 (0.38) | CYP1A2ALDH1A1CYP3A4CYP2C9CASP1 | |
| SCHEMBL401211 | 0.78 | KDR (0.51) | EGFRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5317048 | 0.77 | ALDH1A1 (0.43) | CYP1A2ALDH1A1CYP3A4CYP2C9CASP1 | |
| SCHEMBL401439 | 0.77 | RIPK2 (0.43) | MERTKKCNH2EGFRIGF1RABL1 | |
| SCHEMBL5137414 | 0.76 | IGF1R (0.41) | CYP1A2ALDH1A1CYP3A4TSHRHPGD | |
| SCHEMBL867973 | 0.76 | PIK3CD (0.53) | EGFRERBB2IGF1RPIK3CDPIK3CA | |
| SCHEMBL400087 | 0.75 | KDR (0.43) | EGFRERBB2IGF1RPIK3CDPIK3CA | |
| SCHEMBL400250 | 0.74 | PIK3CD (0.48) | EGFRERBB2IGF1RPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979002-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI Pharmaceuticals, Inc. (US) | 2008-10-15 | — | — | EP | claimed |
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | claimed |
| WO-2007075554-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | WO | claimed |