Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 1/20 | 0.59 |
| ▸ | CDC25B | P30305 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CASP1 | P29466 | 3/20 | 0.46 |
| ▸ | BLM | P54132 | 3/20 | 0.46 |
| ▸ | CASP7 | P55210 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ECE1 | P42892 | 1/20 | 0.39 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29642200 | 1.00 | MAOA (0.59) | MAOAMAOBCDC25BSMN1; SMN2TP53 | |
| SCHEMBL7813936 | 0.90 | MAOA (0.49) | MAOAMAOBCDC25BSMN1; SMN2TP53 | |
| SCHEMBL7819427 | 0.90 | MAOA (0.49) | MAOAMAOBCDC25BSMN1; SMN2TP53 | |
| SCHEMBL7806728 | 0.90 | CDC25B (0.56) | MAOAMAOBCDC25BSMN1; SMN2TP53 | |
| SCHEMBL7810488 | 0.86 | MAPT (0.51) | MAOAMAOBCDC25BSMN1; SMN2TP53 | |
| SCHEMBL7810480 | 0.86 | MAPT (0.51) | MAOAMAOBCDC25BSMN1; SMN2TP53 | |
| SCHEMBL29642348 | 0.81 | ECE1 (0.65) | MAOAMAOBCDC25BSMN1; SMN2TP53 | |
| SCHEMBL29642192 | 0.81 | ECE1 (0.65) | MAOAMAOBCDC25BSMN1; SMN2TP53 | |
| SCHEMBL28381205 | 0.81 | ECE1 (0.65) | MAOAMAOBCDC25BSMN1; SMN2TP53 | |
| SCHEMBL28378350 | 0.81 | ECE1 (0.65) | MAOAMAOBCDC25BSMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752857-B1 | AN IMPROVED METHOD OF SYNTHESIS FOR 6,9-BIS (2-AMINOETHYL)AMINO]BENZO g]ISOQUINOLINE-5,10-DIONE AND ITS DIMALEATE SALT | NOVUSPHARMA SPA (IT) | 2001-07-25 | — | — | EP | claimed |
| US-5717099-A | Method of synthesis for 6,9-bis((2-aminoethyl)amino)benzo g!isoquinoline-5,10-dione and its dimaleate salt | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1998-02-10 | — | — | US | claimed |
| EP-0752857-A1 | AN IMPROVED METHOD OF SYNTHESIS FOR 6,9-BIS (2-AMINOETHYL)AMINO]BENZO g]ISOQUINOLINE-5,10-DIONE AND ITS DIMALEATE SALT | BOEHRINGER MANNHEIM ITALIA S.p.A. (IT) | 1997-01-15 | — | — | EP | claimed |
| WO-1995026189-A1 | AN IMPROVED METHOD OF SYNTHESIS FOR 6,9-BIS[(2-AMINOETHYL)AMINO]BENZO[g]ISOQUINOLINE-5,10-DIONE AND ITS DIMALEATE SALT | BOEHRINGER MANNHEIM ITALIA, S.P.A. (US) | 1995-10-05 | — | — | WO | claimed |
| EP-0503537-A1 | 6,9 Bis(substituted-amino)benzo-[g]isoquinoline-5,10-diones | THE UNIVERSITY OF VERMONT (US) | 1992-09-16 | — | — | EP | claimed |
| CN-114685583-A | Glycoside compounds, preparation method and application thereof | 西格莱(苏州)生物医药有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-110873765-B | Detection method of pixantrone maleate related substance | 北京凯莱天成医药科技有限公司 | 2022-05-17 | — | — | CN | disclosed |
| CN-110873765-A | Detection method of pixantrone maleate related substance | 北京凯莱天成医药科技有限公司 | 2020-03-10 | — | — | CN | disclosed |
| WO-2008103320-A1 | METHODS OF TREATING OPHTHALMIC DISORDERS WITH ANTHRAQUINONES | NOVACEA, INC. (US) | 2008-08-28 | — | — | WO | disclosed |
| WO-2005097128-A1 | 1,4-BIS-N-OXIDE AZAANTHRACENEDIONES AND THE USE THEREOF | NOVACEA, INC. (US) | 2005-10-20 | — | — | WO | disclosed |
| US-20050222190-A1 | 1,4-bis-N-oxide azaanthracenediones and the use thereof | CURD JOHN G | 2005-10-06 | — | — | US | disclosed |
| EP-0752857-B1 | AN IMPROVED METHOD OF SYNTHESIS FOR 6,9-BIS (2-AMINOETHYL)AMINO]BENZO g]ISOQUINOLINE-5,10-DIONE AND ITS DIMALEATE SALT | NOVUSPHARMA SPA (IT) | 2001-07-25 | — | — | EP | disclosed |
| EP-0662076-A1 | 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY | THE UNIVERSITY OF VERMONT (US) | 1995-07-12 | — | — | EP | disclosed |
| EP-0639183-A1 | NITROGEN OXIDES OF AZA- AND DIAZA-ANTHRACENEDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1995-02-22 | — | — | EP | disclosed |
| WO-1994006795-A1 | 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY | THE UNIVERSITY OF VERMONT (US) | 1994-03-31 | — | — | WO | disclosed |
| EP-0575526-A4 | — | — | 1994-03-30 | — | — | EP | disclosed |
| EP-0575526-A1 | 6,9 BIS(SUBSTITUTED-AMINO)BENZO g]ISOQUINOLINE-5,10-DIONES | THE UNIVERSITY OF VERMONT (US) | 1993-12-29 | — | — | EP | disclosed |
| WO-1992015300-A1 | 6,9 BIS(SUBSTITUTED-AMINO)BENZO[g]ISOQUINOLINE-5,10-DIONES | THE UNIVERSITY OF VERMONT (US) | 1992-09-17 | — | — | WO | disclosed |
| WO-1992015566-A1 | NITROGEN OXIDES OF AZA- AND DIAZA-ANTHRACENEDIONE DERIVATIVES AS ANTITUMOR AGENTS | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-09-17 | — | — | WO | disclosed |
| EP-0503537-A1 | 6,9 Bis(substituted-amino)benzo-[g]isoquinoline-5,10-diones | THE UNIVERSITY OF VERMONT (US) | 1992-09-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222190-A1 | 1,4-bis-N-oxide azaanthracenediones and the use thereof | CCND1, BRCA1, CDKN1A | MAOA 967/4885MAOB 904/4885CDC25B 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.