Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.45 |
| ▸ | CTSD | P07339 | 15/20 | 0.44 |
| ▸ | BACE2 | Q9Y5Z0 | 15/20 | 0.44 |
| ▸ | REN | P00797 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782436 | 0.88 | BACE1 (0.45) | BACE1CTSDBACE2RENCYP3A4 | |
| SCHEMBL4783664 | 0.88 | BACE1 (0.60) | BACE1CTSDBACE2REN | |
| SCHEMBL4786860 | 0.86 | BACE1 (0.48) | BACE1CTSDBACE2RENCYP3A4 | |
| SCHEMBL4781222 | 0.85 | BACE1 (0.59) | BACE1CTSDBACE2REN | |
| SCHEMBL4737233 | 0.81 | BACE1 (0.61) | BACE1CTSDBACE2REN | |
| SCHEMBL4737256 | 0.79 | BACE1 (0.62) | BACE1CTSDBACE2REN | |
| SCHEMBL5139272 | 0.77 | BACE1 (0.60) | BACE1CTSDBACE2REN | |
| SCHEMBL4738633 | 0.77 | BACE1 (0.48) | BACE1CTSDBACE2REN | |
| SCHEMBL4734540 | 0.76 | BACE1 (0.50) | BACE1CTSDBACE2RENCYP3A4 | |
| SCHEMBL4516296 | 0.75 | BACE1 (0.64) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076043-A1 | NOVEL 2-AMINO-5,5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |