Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708350 | 0.94 | LRRK2 (0.42) | EGFRLRRK2HTTKDM4ELMNA | |
| SCHEMBL1707947 | 0.94 | LRRK2 (0.43) | EGFRLRRK2HTTKDM4ELMNA | |
| SCHEMBL3423878 | 0.84 | EGFR (0.45) | EGFRHTTKDM4ELMNAHPGD | |
| SCHEMBL5139968 | 0.84 | HTT (0.42) | EGFRHTTKDM4ELMNAHPGD | |
| SCHEMBL5132792 | 0.77 | EGFR (0.50) | EGFRLRRK2HTTKDM4ELMNA | |
| SCHEMBL1755275 | 0.74 | NSD2 (0.57) | EGFRLRRK2HTTKDM4ELMNA | |
| SCHEMBL1706637 | 0.73 | EGFR (0.50) | EGFRLRRK2HTTKDM4ELMNA | |
| SCHEMBL1707567 | 0.73 | NSD2 (0.56) | EGFRLRRK2HTTKDM4ELMNA | |
| SCHEMBL1707506 | 0.73 | EGFR (0.49) | EGFRLRRK2HTTKDM4ELMNA | |
| SCHEMBL1841010 | 0.73 | NSD2 (0.58) | EGFRLRRK2HTTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863283-B2 | Sulphoximine-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments | BAYER SCHERING PHARMA AG (DE) | 2011-01-04 | — | — | US | claimed |