Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 19/20 | 0.82 |
| ▸ | ABL1 | P00519 | 18/20 | 0.82 |
| ▸ | PIK3CD | O00329 | 16/20 | 0.82 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.82 |
| ▸ | PIK3CG | P48736 | 16/20 | 0.82 |
| ▸ | PRKDC | P78527 | 16/20 | 0.82 |
| ▸ | KDR | P35968 | 16/20 | 0.82 |
| ▸ | EGFR | P00533 | 15/20 | 0.82 |
| ▸ | HCK | P08631 | 15/20 | 0.82 |
| ▸ | MTOR | P42345 | 15/20 | 0.82 |
| ▸ | EPHB4 | P54760 | 15/20 | 0.82 |
| ▸ | PIK3CB | P42338 | 15/20 | 0.82 |
| ▸ | PI4KB | Q9UBF8 | 6/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3610512 | 0.90 | SRC (1.00) | SRCABL1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL24907281 | 0.72 | KDR (0.73) | SRCABL1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL2320180 | 0.72 | SRC (1.00) | SRCABL1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL12436141 | 0.71 | SRC (0.72) | SRCABL1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL129811 | 0.70 | PIK3CD (0.63) | SRCABL1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL27753701 | 0.70 | SRC (0.67) | SRCABL1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL14574574 | 0.70 | SRC (0.80) | SRCABL1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL2315798 | 0.70 | SRC (1.00) | SRCABL1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL7901661 | 0.70 | SRC (0.66) | SRCABL1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL28455902 | 0.70 | SRC (0.76) | SRCABL1PIK3CDPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004654-A2 | KINASE ANTAGONISTS | The Regents of the University of California (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007114926-A2 | KINASE ANTAGONISTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-10-11 | — | — | WO | disclosed |