Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.55 |
| ▸ | FLT3 | P36888 | 3/20 | 0.55 |
| ▸ | FRK | P42685 | 2/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.55 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.55 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.55 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.55 |
| ▸ | RET | P07949 | 2/20 | 0.55 |
| ▸ | BCR | P11274 | 1/20 | 0.55 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.55 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.55 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.55 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.55 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.55 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 12/20 | 0.37 |
| ▸ | BRAF | P15056 | 6/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL276273 | 0.88 | FGFR1 (0.69) | FGFR1FLT3FRKMAPK9RPS6KA3 | |
| SCHEMBL10273038 | 0.80 | FGFR1 (0.59) | FGFR1FLT3FRKMAPK9RPS6KA3 | |
| SCHEMBL276616 | 0.79 | FGFR1 (0.69) | FGFR1FLT3FRKMAPK9RPS6KA3 | |
| SCHEMBL9979884 | 0.79 | FLT3 (0.57) | FGFR1FLT3FRKMAPK9RPS6KA3 | |
| SCHEMBL276552 | 0.79 | FGFR1 (0.67) | FGFR1FLT3FRKMAPK9RPS6KA3 | |
| SCHEMBL276467 | 0.78 | FGFR1 (0.66) | FGFR1FLT3FRKMAPK9RPS6KA3 | |
| SCHEMBL5182413 | 0.78 | RET (0.56) | FGFR1FLT3FRKMAPK9RPS6KA3 | |
| SCHEMBL15435525 | 0.76 | FGFR1 (0.64) | FGFR1FLT3FRKMAPK9RPS6KA3 | |
| SCHEMBL9979888 | 0.75 | FGFR1 (0.63) | FGFR1FLT3FRKMAPK9RPS6KA3 | |
| SCHEMBL276489 | 0.74 | FGFR1 (0.73) | FGFR1FLT3FRKMAPK9RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957077-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | Bayer HealthCare LLC (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007064883-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC. (US) | 2007-06-07 | — | — | WO | disclosed |