Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.58 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4904033 | 0.85 | ADORA1 (0.77) | ADORA2AADORA1ADORA2BRXFP1MAPT | |
| SCHEMBL4421002 | 0.82 | RXFP1 (0.61) | ADORA2AADORA1ADORA2BRXFP1MAPT | |
| SCHEMBL15286448 | 0.78 | ADORA1 (0.67) | ADORA2AADORA1ADORA2BRXFP1MAPT | |
| SCHEMBL4908567 | 0.78 | ADORA2A (0.57) | ADORA2AADORA1ADORA2BRXFP1MAPT | |
| SCHEMBL15286427 | 0.73 | ADORA1 (0.67) | ADORA2AADORA1ADORA2BRXFP1MAPT | |
| SCHEMBL4905916 | 0.72 | ADORA1 (0.77) | ADORA2AADORA1ADORA2BRXFP1MAPT | |
| SCHEMBL5937502 | 0.71 | HPGD (0.74) | ADORA2AADORA1ADORA2BRXFP1MAPT | |
| SCHEMBL3369169 | 0.71 | ADORA1 (0.71) | ADORA2AADORA1ADORA2BRXFP1MAPT | |
| SCHEMBL5744860 | 0.71 | ADORA1 (0.60) | ADORA2AADORA1ADORA2BRXFP1MAPT | |
| SCHEMBL5501933 | 0.70 | ADORA1 (0.64) | ADORA2AADORA1ADORA2BRXFP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984377-A2 | INHIBITORS OF TNF ALPHA , PDE4 AND B-RAF, COMPOSITIONS THEREOF AND METHODS OF USE THEREWITH | Signal Pharmaceuticals LLC (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007084560-A2 | INHIBITORS OF TNFα, PDE4 AND B-RAF, COMPOSITIONS THEREOF AND METHODS OF USE THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-07-26 | — | — | WO | disclosed |