Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 6/20 | 0.64 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.48 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18866750 | 0.84 | ADORA2A (0.52) | ADORA1ADORA2AHPGDHTTADORA2B | |
| SCHEMBL15214874 | 0.82 | ADORA1 (0.50) | ADORA1ADORA2AHPGDHTTADORA2B | |
| SCHEMBL8124145 | 0.82 | ADORA1 (0.65) | ADORA1ADORA2AHPGDADORA2BMAPT | |
| SCHEMBL23998166 | 0.81 | ADORA2A (0.58) | ADORA1ADORA2AHPGDHTTADORA2B | |
| SCHEMBL30250859 | 0.81 | ADORA2A (0.58) | ADORA1ADORA2AHPGDHTTADORA2B | |
| SCHEMBL10360609 | 0.79 | ATM (0.44) | ADORA1ADORA2AHPGDHTTADORA2B | |
| SCHEMBL3614512 | 0.79 | ADORA1 (0.47) | ADORA1ADORA2AHPGDHTTADORA2B | |
| SCHEMBL2645516 | 0.78 | ADORA1 (0.58) | ADORA1ADORA2AHPGDADORA2BKMT2A | |
| SCHEMBL15286427 | 0.77 | ADORA1 (0.67) | ADORA1ADORA2AHPGDHTTADORA2B | |
| SCHEMBL15286448 | 0.77 | ADORA1 (0.67) | ADORA1ADORA2AHPGDHTTADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778718-A1 | INHIBITORS OF IAP | Genentech, Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006014361-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2006-02-09 | — | — | WO | disclosed |