Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.37 |
| ▸ | MGLL | Q99685 | 3/20 | 0.37 |
| ▸ | FAAH | O00519 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8791482 | 0.78 | GBA1 (0.40) | GBA1PTGS1PTGS2MGLLFAAH | |
| SCHEMBL7361340 | 0.72 | SMN1; SMN2 (0.36) | GBA1ALDH1A1GAACYP19A1 | |
| SCHEMBL9578281 | 0.70 | GBA1 (0.38) | GBA1PTGS1PTGS2MGLLFAAH | |
| SCHEMBL10915954 | 0.69 | GBA1 (0.42) | GBA1PTGS1PTGS2MGLLFAAH | |
| SCHEMBL8803997 | 0.69 | PLA2G2A (0.47) | GBA1PTGS1PTGS2MGLLFAAH | |
| SCHEMBL4421172 | 0.69 | GBA1 (0.44) | GBA1PTGS1PTGS2MGLLFAAH | |
| SCHEMBL9769271 | 0.67 | GBA1 (0.47) | GBA1PTGS1PTGS2MGLLFAAH | |
| SCHEMBL9769185 | 0.67 | GBA1 (0.47) | GBA1PTGS1PTGS2MGLLFAAH | |
| SCHEMBL9617015 | 0.67 | GBA1 (0.47) | GBA1PTGS1PTGS2MGLLFAAH | |
| SCHEMBL31093244 | 0.67 | GBA1 (0.47) | GBA1PTGS1PTGS2MGLLFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080070874-A1 | using retinoid or tetracycline as bactericide, benzoyl peroxide as metalloproteinases (MMPs) and neutrophil elastase inhibitors; antiscarring agents; reduction in procollagen biosynthesis | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2008-03-20 | — | — | US | disclosed |
| US-7268148-B2 | Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2007-09-11 | — | — | US | disclosed |
| US-20060009494-A1 | Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes | VOORHEES JOHN J | 2006-01-12 | — | — | US | disclosed |
| US-20050277695-A1 | Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes | VOORHEES JOHN J | 2005-12-15 | — | — | US | disclosed |
| US-20040235950-A1 | Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes | REGENTS OF THE UNIVERSITY OF MICHIGAN, THE | 2004-11-25 | — | — | US | disclosed |
| EP-1284721-A2 | COMPOSITIONS AND METHODS FOR USE AGAINST ACNE-INDUCED INFLAMMATION AND DERMAL MATRIX-DEGRADING ENZYMES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2003-02-26 | — | — | EP | disclosed |
| WO-2001089502-A2 | COMPOSITIONS AND METHODS FOR USE AGAINST ACNE-INDUCED INFLAMMATION AND DERMAL MATRIX-DEGRADING ENZYMES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2001-11-29 | — | — | WO | disclosed |