Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 19/20 | 0.41 |
| ▸ | AKT2 | P31751 | 19/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL513393 | 1.00 | AKT1 (0.41) | AKT1AKT2XIAP | |
| SCHEMBL513224 | 0.92 | AKT1 (0.39) | AKT1AKT2 | |
| SCHEMBL513225 | 0.92 | AKT1 (0.39) | AKT1AKT2 | |
| SCHEMBL514254 | 0.91 | AKT1 (0.39) | AKT1AKT2 | |
| SCHEMBL514077 | 0.91 | AKT1 (0.39) | AKT1AKT2 | |
| SCHEMBL14876755 | 0.89 | XIAP (0.37) | AKT1AKT2XIAP | |
| SCHEMBL14876756 | 0.89 | XIAP (0.37) | AKT1AKT2XIAP | |
| SCHEMBL513990 | 0.86 | XIAP (0.33) | XIAP | |
| SCHEMBL513862 | 0.85 | NAMPT (0.41) | AKT1AKT2XIAP | |
| SCHEMBL513863 | 0.85 | NAMPT (0.41) | AKT1AKT2XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130102605-A1 | INHIBITORS OF AKT ACTIVITY | LIANG PENG (CN) | 2013-04-25 | — | — | US | claimed |
| US-20130102605-A1 | INHIBITORS OF AKT ACTIVITY | LIANG PENG (CN) | 2013-04-25 | — | — | US | disclosed |
| US-20120028918-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF MAKING SAME | GLAXO WELLCOME MANUFACTURING PTE LTD. (SG) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028918-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF MAKING SAME | PIK3CA, G6PC1, PIK3C2B | AKT1 172/4885AKT2 121/4885XIAP 994/4885 |
| US-20130102605-A1 | INHIBITORS OF AKT ACTIVITY | PIK3CA, PIK3CD, AKT2 | AKT1 8/4885AKT2 3/4885XIAP 750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.