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Sugi Predict / Targets / G6PC1

G6PC1

Glucose-6-phosphatase catalytic subunit 1 · P35575 · G6PC1 on Sugi Atlas →

3,790 patent compounds predicted against G6PC1, 2,205 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1793162 SCHEMBL1793162 0.50 14/20
SCHEMBL3413430 SCHEMBL3413430 0.52 10/20
SCHEMBL3869799 SCHEMBL3869799 0.69 9/20
SCHEMBL3869803 SCHEMBL3869803 0.69 9/20
SCHEMBL130652 SCHEMBL130652 0.55 8/20
SCHEMBL170198 SCHEMBL170198 0.55 6/20
SCHEMBL332653 SCHEMBL332653 0.55 6/20
SCHEMBL1164804 SCHEMBL1164804 0.50 5/20
SCHEMBL1164805 SCHEMBL1164805 0.50 5/20
SCHEMBL4748290 SCHEMBL4748290 0.49 5/20
SCHEMBL4885008 SCHEMBL4885008 0.49 5/20
SCHEMBL987853 SCHEMBL987853 0.50 4/20
SCHEMBL987854 SCHEMBL987854 0.50 4/20
SCHEMBL6142821 SCHEMBL6142821 0.45 4/20
SCHEMBL5550246 SCHEMBL5550246 0.42 4/20
SCHEMBL6598520 SCHEMBL6598520 0.44 3/20
SCHEMBL332093 SCHEMBL332093 0.44 3/20
SCHEMBL332094 SCHEMBL332094 0.44 3/20
SCHEMBL139345 SCHEMBL139345 0.39 3/20
SCHEMBL1131502 SCHEMBL1131502 0.54 2/20

Clinical trials — most relevant to G6PC1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Acute Effects of an Oral Fat Load on Skeletal Muscle and Hepatic Insulin Sensitivity PHASE4COMPLETED
Rapid Effects of Hydrocortisone on Glucose-induced Insulin Secretion in Healthy Humans PHASE4COMPLETED
SGLT2 Inhibition and Stimulation of Endogenous Glucose Production: Protocol 2 PHASE3COMPLETED
Safety, Efficacy Evaluation of Empagliflozin Administration for Neutropenia in Glycogenosis Type 1b and G6PC3 Deficiency PHASE2UNKNOWN
Endogenous Glucose Production in Patients With Glycogen Storage Disease Type Ia PHASE1/PHASE2COMPLETED
A Multi-center 12-week Study of HMS5552 in T2DM PHASE2COMPLETED
Efficacy and Safety of Empagliflozin in GSD-Ib Patients PHASE2WITHDRAWN
Liver Glycogen and Hypoglycemia in Humans PHASE1ACTIVE_NOT_RECRUITING
Multiple Ascending Doses of Globalagliatin Hydrochloride in Type 2 Diabetes Mellitus PHASE1COMPLETED
Contribution of Hyperinsulinemia vs. Hyperglycemia to Insulin Resistance in Type 1 Diabetes and Maturity Onset Diabetes of the Young, Type 2 (MODY2) PHASE1COMPLETED
Role of the Liver in Glucose Homeostasis Using Metabolic Imaging nanCOMPLETED
GSD VI and GSD IX Natural History nanRECRUITING
Biomarker for Glycogen Storage Diseases (BioGlycogen) nanWITHDRAWN
Effect of Meal Timing in T2D on Hepatocytes SRIT1 and Clock Genes nanUNKNOWN
Dried Fruit and Postprandial Glycemia Trial nanUNKNOWN
Effect of Glucagon on Fasting Insulin Secretion and Glucose Metabolism in Subjects Without Type 2 Diabetes nanRECRUITING
Effect of an Polyphenolic Beverage in Healthy Volunteers nanACTIVE_NOT_RECRUITING
Effects of Polyphenols Found in Pomegranate and Olives Food Supplements on Postprandial Blood Glucose in Vivo. nanCOMPLETED
The Study of HIV Protease Inhibitors and Their Effects on Glucose Metabolism nanCOMPLETED
Efficacy of Physical Exercise on Glucose Control in People With Prediabetes (GLYCEX) - Phase II nanUNKNOWN
Study to Evaluate Biomarkers and Clinical Manifestations in Individuals With Glycogen Storage Disease Type III (GSD III) nanCOMPLETED
Predisposition Genes in Monogenic Diabetes (DIAMONO) nanCOMPLETED
Effect of Short-Term Exercise Training on ATP Synthesis in Relatives of Type 2 Diabetic Humans nanCOMPLETED
Sleep and Quality of Life in Patients With Glycogen Storage Disease on Standard Versus Modified Uncooked Cornstarch nanCOMPLETED
Exercise in Type 1 Diabetes Mellitus nanCOMPLETED
McArdle Disease Treatment by Ketogenic Diet nanCOMPLETED
Effects of Polyphenols Found in Pomegranate Juice on Postprandial Blood Glucose in Vivo nanCOMPLETED
Effects of Dual-Source Carbohydrate Intake and Liver Glycogen Repletion After Overnight Fasting. nanNOT_YET_RECRUITING
Malaria Surveillance in Rakai, Uganda nanCOMPLETED
Dual PETOvac - Dual Time PET/CT in the Preoperative Assessment of Ovarian Cancer nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a G6PC1 binder may also engage these)

ProteinNameSimilarity
Q19KA1 — 1.000 Q19KA1 →
P35576 — 1.000 P35576 →
Q29RU6 — 1.000 Q29RU6 →
P43428 — 0.999 P43428 →
O19133 — 0.996 O19133 →
Q9BUM1 — 0.979 Q9BUM1 →
Q9Z186 — 0.979 Q9Z186 →
Q9NQR9 — 0.978 Q9NQR9 →
Q6NSQ9 — 0.974 Q6NSQ9 →
A1A5Z0 — 0.971 A1A5Z0 →
O42153 — 0.969 O42153 →
Q148G2 — 0.968 Q148G2 →
Q9JI99 — 0.967 Q9JI99 →
Q9NX78 — 0.965 Q9NX78 →
Q99P55 — 0.961 Q99P55 →
Q8BMD6 — 0.959 Q8BMD6 →
Q6AZ83 — 0.959 Q6AZ83 →
Q91WB2 — 0.957 Q91WB2 →
Q5FVJ3 — 0.956 Q5FVJ3 →
Q5GH61 — 0.956 Q5GH61 →
O42154 — 0.954 O42154 →
P51811 — 0.954 P51811 →
Q9JJJ7 — 0.953 Q9JJJ7 →
Q49LS5 — 0.952 Q49LS5 →
Q6DED0 — 0.952 Q6DED0 →
Q9M2G7 — 0.952 Q9M2G7 →
Q9QXY7 — 0.952 Q9QXY7 →
Q8TCT6 — 0.952 Q8TCT6 →
Q9DBN1 — 0.952 Q9DBN1 →
Q5R7Z3 — 0.951 Q5R7Z3 →