Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | RAD52 | P43351 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RGS12 | O14924 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15157507 | 0.98 | PTPN1 (0.56) | PTPN1MEN1KMT2AATMNPC1 | |
| Iodide SCHEMBL22390070 | 0.90 | PTPN1 (0.47) | PTPN1MEN1KMT2AATMNPC1 | |
| SCHEMBL15156667 | 0.88 | MEN1 (0.44) | PTPN1MEN1KMT2AATMNPC1 | |
| Iodide SCHEMBL25434164 | 0.84 | PTPN1 (0.56) | PTPN1MEN1KMT2AATMNPC1 | |
| SCHEMBL25387252 | 0.83 | PTPN1 (0.54) | PTPN1MEN1KMT2AATMNPC1 | |
| Water SCHEMBL25434773 | 0.81 | PTPN1 (0.52) | PTPN1MEN1KMT2AATMNPC1 | |
| SCHEMBL3457693 | 0.81 | KDM4E (0.49) | PTPN1MEN1KMT2AAPOBEC3AAPOBEC3G | |
| Iodide SCHEMBL5146457 | 0.79 | PTPN1 (0.47) | PTPN1MEN1KMT2AATMNPC1 | |
| SCHEMBL3834206 | 0.79 | APOBEC3A (0.40) | PTPN1APOBEC3AAPOBEC3GKDM4EHTT | |
| SCHEMBL10325415 | 0.77 | APOBEC3A (0.43) | PTPN1MEN1KMT2ANPC1APOBEC3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7273953-B2 | Process for producing arylamine | FUJIFILM FINECHEMICALS CO., LTD. (JP) | 2007-09-25 | — | — | US | disclosed |
| US-20060069287-A1 | Process for producing arylamine | FUJIFILM FINECHEMICALS CO., LTD. (JP) | 2006-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069287-A1 | Process for producing arylamine | TYR, AADAC, AOC2 | PTPN1 1428/4885MEN1 3458/4885KMT2A 352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.