Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | SNCA | P37840 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | NEK2 | P51955 | 2/20 | 0.32 |
| ▸ | ILK | Q13418 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1379573 | 0.92 | APP (0.39) | APPMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL1379571 | 0.92 | APP (0.39) | APPMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL1379586 | 0.90 | APP (0.41) | APPMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL1379587 | 0.90 | APP (0.41) | APPMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL1376039 | 0.90 | MAPT (0.47) | APPMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL1376041 | 0.90 | MAPT (0.47) | APPMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL1375570 | 0.89 | APP (0.40) | APPMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL1376393 | 0.89 | APP (0.42) | APPMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL1379601 | 0.89 | APP (0.40) | APPMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL1376394 | 0.89 | APP (0.42) | APPMEN1MAPTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7285562-B2 | Cyanoamide compounds useful as malonyl-CoA decarboxylase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2007-10-23 | — | — | US | disclosed |
| EP-1648564-B1 | CYANOAMIDE COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITORS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2007-10-17 | — | — | EP | disclosed |
| EP-1648564-A1 | CYANOAMIDE COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005011812-A1 | CYANOAMIDE COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITHORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-02-10 | — | — | WO | disclosed |
| US-20050026945-A1 | Cyanoamide compounds useful as malonyl-CoA decarboxylase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026945-A1 | Cyanoamide compounds useful as malonyl-CoA decarboxylase inhibitors | ACACA, ACACB, MCCC2 | APP 2169/4885MEN1 1792/4885MAPT 2998/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.