Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 3/20 | 0.50 |
| ▸ | RET | P07949 | 2/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | FRK | P42685 | 2/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.50 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.50 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.50 |
| ▸ | BCR | P11274 | 1/20 | 0.50 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.50 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.50 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.50 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.50 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.50 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.50 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 8/20 | 0.47 |
| ▸ | RAF1 | P04049 | 2/20 | 0.47 |
| ▸ | BRAF | P15056 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL59668 | 0.92 | FLT3 (0.58) | IKBKEFLT3RETFGFR1FRK | |
| SCHEMBL5157669 | 0.92 | RET (0.53) | IKBKEFLT3RETFGFR1FRK | |
| SCHEMBL57858 | 0.86 | FLT3 (0.57) | IKBKEFLT3RETFGFR1FRK | |
| SCHEMBL59289 | 0.84 | FLT3 (0.61) | IKBKEFLT3RETFGFR1FRK | |
| SCHEMBL58646 | 0.84 | IKBKE (0.63) | IKBKEFLT3RETFGFR1FRK | |
| SCHEMBL59646 | 0.84 | FLT3 (0.61) | IKBKEFLT3RETFGFR1FRK | |
| SCHEMBL58577 | 0.83 | ERN1 (0.55) | IKBKEFLT3RETFGFR1FRK | |
| SCHEMBL64952 | 0.82 | ACVRL1 (0.51) | IKBKEFLT3RETFGFR1FRK | |
| SCHEMBL57821 | 0.81 | IKBKE (0.60) | IKBKEFLT3RETFGFR1FRK | |
| SCHEMBL59383 | 0.81 | FLT3 (0.59) | IKBKEFLT3RETFGFR1FRK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957485-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | Bayer Healthcare, LLC (US) | 2008-08-20 | — | — | EP | claimed |
| WO-2007064931-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2007-06-07 | — | — | WO | claimed |