2,4-Dichlorophenol

2,4-Dichlorophenol

SCHEMBL5144446

O=C(O)O.Oc1ccc(Cl)cc1Cl.Oc1ccc(Cl)cc1Cl

nearest known ligand 0.81

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GSK3AGSK3BIMPA1

The experimentally established mechanism targets of 2,4-Dichlorophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 5/20 0.81
TSHR P16473 4/20 0.81
CA2 P00918 3/20 0.59
CA1 P00915 2/20 0.59
SMN1; SMN2 Q16637 3/20 0.56
CASP1 P29466 2/20 0.56
ALDH1A1 P00352 4/20 0.52
CYP3A4 P08684 3/20 0.52
TDP1 Q9NUW8 2/20 0.52
TP53 P04637 2/20 0.50
POLB P06746 1/20 0.48
ESR2 Q92731 1/20 0.48
ERN1 O75460 1/20 0.48
HPGD P15428 4/20 0.48
ALOX15 P16050 3/20 0.48
ALOX12 P18054 2/20 0.48
MAPK1 P28482 1/20 0.48
TTR P02766 1/20 0.47
MEN1 O00255 2/20 0.46
HSP90AA1 P07900 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2,4-Dichlorophenol SCHEMBL16752519 0.91 HSD17B10 (0.74) HSD17B10TSHRCA2CA1SMN1; SMN2
2,4-Dichlorophenol SCHEMBL30084868 0.90
2,4-Dichlorophenol SCHEMBL77936 0.90
2,4-Dichlorophenol SCHEMBL30396784 0.90
2,4-Dichlorophenol SCHEMBL8526331 0.87 HSD17B10 (0.94) HSD17B10TSHRCA2CA1SMN1; SMN2
2,4-Dichlorophenol SCHEMBL29404519 0.87 HSD17B10 (0.94) HSD17B10TSHRCA2CA1SMN1; SMN2
2,4-Dichlorophenol SCHEMBL28226615 0.87 HSD17B10 (0.94) HSD17B10TSHRCA2CA1SMN1; SMN2
2,4-Dichlorophenol SCHEMBL7394579 0.87 HSD17B10 (0.94) HSD17B10TSHRCA2CA1SMN1; SMN2
2,4-Dichlorophenol SCHEMBL28227287 0.87 HSD17B10 (0.94) HSD17B10TSHRCA2CA1SMN1; SMN2
2,4-Dichlorophenol SCHEMBL28227282 0.87 HSD17B10 (0.94) HSD17B10TSHRCA2CA1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1430362-A4 PHOTOCONDUCTORS COMPRISING CYCLIC CARBONATE POLYMERS LEXMARK INT INC (US) 2007-03-21 EP disclosed
EP-1430362-A1 PHOTOCONDUCTORS COMPRISING CYCLIC CARBONATE POLYMERS Lexmark International, Inc. (US) 2004-06-23 EP disclosed
WO-2002099535-A1 PHOTOCONDUCTORS COMPRISING CYCLIC CARBONATE POLYMERS LEXMARK INTERNATIONAL, INC. (US) 2002-12-12 WO disclosed
US-6489070-B1 Photoconductors comprising cyclic carbonate polymers LEXMARK INTERNATIONAL, INC. 2002-12-03 US disclosed