SCHEMBL5144644

SCHEMBL5144644

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nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2742888 1.00
SCHEMBL394265 1.00
SCHEMBL469701 0.87 ALDH1A1 (0.32)
SCHEMBL27937983 0.82 SLC22A6 (0.46)
SCHEMBL196713 0.81
SCHEMBL28518627 0.80
SCHEMBL875272 0.78
SCHEMBL3494850 0.77
SCHEMBL3501156 0.74
SCHEMBL1139057 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070037263-A1 Novel acetoacetyl-coa reductase and process for producing optically active alcohol KANEKA CORPORATION (JP) 2007-02-15 US claimed
EP-1688480-A2 NOVEL ACETOACETYL-CoA REDUCTASE AND PROCESS FOR PRODUCING OPTICALLY ACTIVE ALCOHOL KANEKA CORPORATION (JP) 2006-08-09 EP claimed
US-6960680-B2 Manufacture of water-soluble β-hydroxynitriles RHODIA CHIREX, INC. (US) 2005-11-01 US claimed
US-9303001-B2 Intermediate of statin drugs and preparation thereof SUNSHINE LAKE PHARMA CO., LTD. (CN) 2016-04-05 US disclosed
EP-1576108-B1 NITRILASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM BASF ENZYMES LLC (US) 2015-07-08 EP disclosed
US-20140206883-A1 INTERMEDIATE OF STATIN DRUGS AND PREPARATION THEREOF YICHANG CHANGJIANG PHARMACEUTICAL CO., LTD. (CN) 2014-07-24 US disclosed
US-20100009426-A1 synthetic or recombinant polypeptide having a nitrilase activity; have increased activity and stability at increased pH and temperature VERENIUM CORPORATION (US) 2010-01-14 US disclosed
US-7374926-B2 Enantioconvergent chemoenzymatic synthesis of (R)-γ-amino-β-hydroxybutyric acid ((R)-GABOB) COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2008-05-20 US disclosed
CN-1325470-C Production method of water-soluble beta-hydroxynitriles RHODIA PHARMA SOLUTIONS INC (US) 2007-07-11 CN disclosed
EP-1581482-A4 MANUFACTURE OF WATER-SOLUBLE BETA-HYDROXYNITRILES RHODIA PHARMA SOLUTIONS INC (US) 2007-04-04 EP disclosed
US-20070037263-A1 Novel acetoacetyl-coa reductase and process for producing optically active alcohol KANEKA CORPORATION (JP) 2007-02-15 US disclosed
US-6960680-B2 Manufacture of water-soluble β-hydroxynitriles RHODIA CHIREX, INC. (US) 2005-11-01 US disclosed
EP-1581482-A1 MANUFACTURE OF WATER-SOLUBLE BETA-HYDROXYNITRILES Rhodia Pharma Solutions Inc. (US) 2005-10-05 EP disclosed
WO-2005044973-A3 NOVEL ACETOACETYL-CoA REDUCTASE AND PROCESS FOR PRODUCING OPTICALLY ACTIVE ALCOHOL KANEKA CORP (JP) 2005-06-30 WO disclosed
WO-2005044973-A2 NOVEL ACETOACETYL-CoA REDUCTASE AND PROCESS FOR PRODUCING OPTICALLY ACTIVE ALCOHOL KANEKA CORP (JP) 2005-05-19 WO disclosed
US-20040235124-A1 Process for production of optically active 3-hydroxy-pentanenitrile KANEKA CORPORATION (JP) 2004-11-25 US disclosed
EP-1452603-A1 PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE 3-HYDROXY- PENTANENITRILE KANEKA CORPORATION (JP) 2004-09-01 EP disclosed
WO-2004063144-A1 MANUFACTURE OF WATER-SOLUBLE β-HYDROXYNITRILES RHODIA PHARMA SOLUTIONS INC. (US) 2004-07-29 WO disclosed
US-20040133029-A1 Manufacture of water-soluble beta-hydroxynitriles RHODIA CHIREX, INC. 2004-07-08 US disclosed
JP-2004180597-A METHOD FOR PRODUCING OPTICALLY ACTIVE 3-HYDROXYPENTANENITRILE AND 3-ACYLOXYPENTANENITRILE KANEGAFUCHI CHEM IND CO LTD 2004-07-02 JP disclosed