Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | ECE1 | P42892 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7701970 | 0.87 | NPC1 (0.45) | TSHRNPC1RAB9ACA1CA2 | |
| SCHEMBL5142558 | 0.87 | NPC1 (0.45) | TSHRNPC1RAB9ACA1CA2 | |
| SCHEMBL29779150 | 0.86 | ELANE (0.49) | TSHRNPC1RAB9ACA1CA2 | |
| SCHEMBL27710787 | 0.86 | ELANE (0.49) | TSHRNPC1RAB9ACA1CA2 | |
| SCHEMBL7701967 | 0.85 | NPC1 (0.46) | NPC1RAB9ACA1CA2MMP2 | |
| SCHEMBL4282571 | 0.84 | CA1 (0.46) | TSHRNPC1RAB9ACA1CA2 | |
| SCHEMBL7214212 | 0.84 | NPC1 (0.47) | TSHRNPC1RAB9ACA1CA2 | |
| SCHEMBL4265208 | 0.84 | NPC1 (0.47) | TSHRNPC1RAB9ACA1CA2 | |
| SCHEMBL4282703 | 0.84 | CA1 (0.46) | TSHRNPC1RAB9ACA1CA2 | |
| SCHEMBL27536452 | 0.84 | CA1 (0.46) | TSHRNPC1RAB9ACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1594976-A4 | ARYL PHOSPHATE DERIVATIVES OF d4T HAVING ACTIVITY AGAINST RESISTANT HIV STRAINS | PARKER HUGHES INST (US) | 2007-11-07 | — | — | EP | disclosed |
| EP-1594976-A2 | ARYL PHOSPHATE DERIVATIVES OF d4T HAVING ACTIVITY AGAINST RESISTANT HIV STRAINS | Parker Hughes Institute (US) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004040002-A2 | ARYL PHOSPHATE DERIVATIVES OF d4T HAVING ACTIVITY AGAINST RESISTANT HIV STRAINS | PARKER HUGHES INSTITUTE (US) | 2004-05-13 | — | — | WO | disclosed |
| EP-1090018-A1 | ARYL PHOSPHATE DERIVATIVES OF d4T HAVING ANTI-HIV ACTIVITY | Parker Hughes Institute (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000501-A1 | ARYL PHOSPHATE DERIVATIVES OF d4T HAVING ANTI-HIV ACTIVITY | PARKER HUGHES INSTITUTE (US) | 2000-01-06 | — | — | WO | disclosed |