Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | ECE1 | P42892 | 1/20 | 0.41 |
| ▸ | CETP | P11597 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5142558 | 1.00 | NPC1 (0.45) | NPC1RAB9ACA1CA2MMP2 | |
| SCHEMBL7701967 | 0.90 | NPC1 (0.46) | NPC1RAB9ACA1CA2MMP2 | |
| SCHEMBL4282703 | 0.89 | CA1 (0.46) | NPC1RAB9ACA1CA2MMP2 | |
| SCHEMBL7214212 | 0.89 | NPC1 (0.47) | NPC1RAB9ACA1CA2MMP2 | |
| SCHEMBL4265208 | 0.89 | NPC1 (0.47) | NPC1RAB9ACA1CA2MMP2 | |
| SCHEMBL4282571 | 0.89 | CA1 (0.46) | NPC1RAB9ACA1CA2MMP2 | |
| SCHEMBL27536452 | 0.89 | CA1 (0.46) | NPC1RAB9ACA1CA2MMP2 | |
| SCHEMBL1287355 | 0.87 | CA1 (0.47) | NPC1RAB9ACA1CA2MMP2 | |
| SCHEMBL5144950 | 0.87 | TSHR (0.42) | NPC1RAB9ACA1CA2MMP2 | |
| SCHEMBL7207832 | 0.86 | MEN1 (0.41) | CA1CA2MMP2CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117486959-A | Synthesis of phosphate derivatives | 努卡那有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-110753697-B | Synthesis of Phosphate Derivatives | 努卡那有限公司 | 2023-10-13 | — | — | CN | disclosed |
| CN-110753697-A | Synthesis of phosphate derivatives | 努卡那有限公司 | 2020-02-04 | — | — | CN | disclosed |
| US-6350736-B1 | phenyl methoxyalaninyl phosphate derivatives of 2',3'-didehydro-2',3'-dideoxythymidine with an electron-withdrawing moiety, such as p-bromo, for enhanced hydrolysis, have increased potency without high cytotoxic activity; inhibitors of HIV reverse transcriptase; thymidine-kinase (TK)-deficient cells | PARKER HUGHES INSTITUTE | 2002-02-26 | — | — | US | disclosed |