Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 5/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | FRK | P42685 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.39 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.39 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.39 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.39 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.39 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.38 |
| ▸ | MOK | Q9UQ07 | 3/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL58527 | 0.92 | ACVRL1 (0.59) | ACVRL1MAPK14RETMAPK9FGFR1 | |
| SCHEMBL58758 | 0.86 | ACVRL1 (0.59) | ACVRL1RETMAPK9FGFR1BCR | |
| SCHEMBL59023 | 0.84 | ACVRL1 (0.60) | ACVRL1MAPK14RETMAPK9FGFR1 | |
| SCHEMBL59349 | 0.83 | ACVRL1 (0.55) | ACVRL1MAPK14RETMAPK9FGFR1 | |
| SCHEMBL58322 | 0.82 | ACVRL1 (0.61) | ACVRL1RETMAPK9FGFR1BCR | |
| SCHEMBL59430 | 0.81 | ACVRL1 (0.52) | ACVRL1MAPK14RETMAPK9FGFR1 | |
| SCHEMBL59381 | 0.80 | ACVRL1 (0.59) | ACVRL1MAPK14RETMAPK9FGFR1 | |
| SCHEMBL58291 | 0.79 | ACVRL1 (0.59) | ACVRL1RETMAPK9FGFR1BCR | |
| SCHEMBL65977 | 0.78 | RET (0.59) | ACVRL1RETMAPK9FGFR1BCR | |
| SCHEMBL58558 | 0.78 | RET (0.54) | ACVRL1MAPK14RETMAPK9FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957485-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | Bayer Healthcare, LLC (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007064931-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2007-06-07 | — | — | WO | disclosed |