Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 8/20 | 0.47 |
| ▸ | CNR2 | P34972 | 7/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 7/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5584867 | 0.96 | CNR1 (0.50) | CNR1CNR2S1PR1ADAMTS5MMP2 | |
| SCHEMBL5585088 | 0.92 | CNR1 (0.53) | CNR1CNR2S1PR1ADAMTS5MMP2 | |
| SCHEMBL5585077 | 0.90 | CNR1 (0.53) | CNR1CNR2S1PR1ADAMTS5MMP2 | |
| SCHEMBL5177950 | 0.85 | CNR1 (0.48) | CNR1CNR2S1PR1ADAMTS5MMP2 | |
| SCHEMBL5142976 | 0.82 | CNR1 (0.61) | CNR1CNR2 | |
| SCHEMBL14512665 | 0.82 | CNR1 (0.48) | CNR1CNR2LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL5147300 | 0.81 | CNR1 (0.59) | CNR1CNR2ADAMTS5MMP2 | |
| SCHEMBL5145056 | 0.79 | CNR1 (0.53) | CNR1CNR2S1PR1 | |
| SCHEMBL5147478 | 0.74 | CNR1 (0.61) | CNR1CNR2S1PR1ADAMTS5MMP2 | |
| SCHEMBL5147420 | 0.73 | CNR1 (0.71) | CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663113-A4 | SUBSTITUTED SULFONAMIDES | MERCK & CO INC (US) | 2007-06-13 | — | — | EP | claimed |
| EP-1663113-A2 | SUBSTITUTED SULFONAMIDES | Merck & Co., Inc. (US) | 2006-06-07 | — | — | EP | claimed |
| WO-2005027837-A2 | SUBSTITUTED SULFONAMIDES | MERCK & CO., INC. (US) | 2005-03-31 | — | — | WO | claimed |