Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | BAD | Q92934 | 1/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | APEX1 | P27695 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147466 | 0.84 | MEN1 (0.44) | ALDH1A1KDM4ETDP1MAPTAPEX1 | |
| SCHEMBL5146594 | 0.84 | ALDH1A1 (0.55) | PTPN1ALDH1A1KDM4ETDP1MAPT | |
| SCHEMBL5147288 | 0.72 | GSK3B (0.44) | ALDH1A1KDM4EHPGDGSK3AGSK3B | |
| SCHEMBL5181927 | 0.71 | SIRT2 (0.46) | PTPN1ALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL5145012 | 0.71 | MEN1 (0.42) | ALDH1A1KDM4ETDP1MAPTL3MBTL1 | |
| SCHEMBL5143420 | 0.70 | PIM1 (0.46) | ALDH1A1KDM4EGSK3AGSK3BTDP1 | |
| SCHEMBL3054179 | 0.69 | ALDH1A1 (0.70) | PTPN1ALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL5145369 | 0.68 | PTPN1 (0.43) | ENPP2PTPN1ALDH1A1KDM4ELMNA | |
| SCHEMBL5146624 | 0.65 | MEN1 (0.69) | KDM4EGSK3AGSK3BINSRIGF1R | |
| SCHEMBL5145164 | 0.65 | KDM4E (0.48) | PTPN1ALDH1A1KDM4EHPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718308-A4 | METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY | PAINCEPTOR PHARMA CORP (CA) | 2007-07-18 | — | — | EP | disclosed |
| EP-1718308-A2 | METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY | PainCeptor Pharma Corp. (CA) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005076695-A2 | METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY | PAINCEPTOR PHARMA CORPORATION (CA) | 2005-08-25 | — | — | WO | disclosed |