Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 20/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5138883 | 0.87 | GPR119 (0.70) | GPR119CYP2C9KCNH2 | |
| SCHEMBL6531969 | 0.87 | GPR119 (0.56) | GPR119CYP2C9KCNH2 | |
| SCHEMBL5138895 | 0.85 | GPR119 (0.51) | GPR119CYP2C9KCNH2 | |
| SCHEMBL389538 | 0.83 | GPR119 (0.73) | GPR119CYP2C9KCNH2 | |
| SCHEMBL388248 | 0.83 | GPR119 (0.73) | GPR119CYP2C9KCNH2 | |
| SCHEMBL388249 | 0.83 | GPR119 (0.73) | GPR119CYP2C9KCNH2 | |
| SCHEMBL5139561 | 0.83 | GPR119 (0.50) | GPR119CYP2C9 | |
| SCHEMBL5140388 | 0.82 | GPR119 (0.50) | GPR119CYP2C9KCNH2 | |
| SCHEMBL5140322 | 0.82 | GPR119 (0.61) | GPR119CYP2C9KCNH2 | |
| SCHEMBL5140401 | 0.81 | GPR119 (0.49) | GPR119CYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470699-B2 | Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto | ARENA PHARMACEUTICALS, INC. (US) | 2008-12-30 | — | — | US | disclosed |