SCHEMBL5146789

SCHEMBL5146789

CC(O)NCCC#N

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL297924 0.79
Hydrochloric Acid SCHEMBL5595671 0.77
SCHEMBL5146762 0.76
SCHEMBL5707589 0.76
SCHEMBL13850664 0.75 TSHR (0.37)
SCHEMBL31424303 0.75 TSHR (0.42)
SCHEMBL525195 0.74 LMNA (0.36)
SCHEMBL11197516 0.73
SCHEMBL5736275 0.73 SLC1A2 (0.36)
SCHEMBL11581422 0.73 SLC1A2 (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1215196-B1 Selective reductive amination of nitriles AIR PROD & CHEM (US) 2004-05-12 EP claimed
EP-0913388-B1 Hydrogenation of nitriles to produce amines AIR PROD & CHEM (US) 2003-10-01 EP claimed
EP-1094058-B1 Selective reductive amination of nitriles AIR PROD & CHEM (US) 2003-09-03 EP claimed
EP-1215196-A1 Selective reductive amination of nitriles AIR PRODUCTS AND CHEMICALS, INC. (US) 2002-06-19 EP claimed
US-6399830-B1 USING CATALYST AIR PRODUCTS AND CHEMICALS, INC. 2002-06-04 US claimed
US-6248925-B1 REACTING A NITRILE WITH A PRIMARY OR SECONDARY AMINE EFFECTING CONVERSION OF THE NITRILE GROUP TO THE CORRESPONDING SECONDARY OR TERTIARY AMINE; PROMOTIONALLY EFFECTIVE AMOUNT OF A LITHIUM COMPOUND OR SODIUM CHLORIDE. AIR PRODUCTS AND CHEMICALS, INC. 2001-06-19 US claimed
EP-1094058-A1 Selective reductive amination of nitriles AIR PRODUCTS AND CHEMICALS, INC. (US) 2001-04-25 EP claimed
EP-0913388-A1 Hydrogenation of nitriles to produce amines AIR PRODUCTS AND CHEMICALS, INC. (US) 1999-05-06 EP claimed
US-5869653-A USING SPONGE OR RANEY COBALT CATALYST; AMMONIA-FREE REACTION AIR PRODUCTS AND CHEMICALS, INC. (US) 1999-02-09 US claimed
EP-0323399-B1 OPTICAL BRIGHTENER DISPERSION CIBA-GEIGY AG (CH) 1993-02-17 EP claimed
EP-0323399-A1 Optical brightener dispersion CIBA-GEIGY AG (CH) 1989-07-05 EP claimed
US-4404167-A AMINO NITRILE INHIBITORS ROZENFELD IOSIF L 1983-09-13 US claimed
CN-113149850-A Process for continuously preparing N-hydroxyethyl-1, 3-propane diamine by using micro-mixing and fixed bed reactor 大连理工大学 2021-07-23 CN disclosed
EP-1697303-A4 CATALYTIC HYDROGENATION OF NITRILES TO PRODUCE CAPSAICINOID DERIVATIVES AND AMINE COMPOUNDS, AND METHODS FOR PURIFIYING AND OBTAINING THE POLYMORPHS THEREOF STIEFEL LABORATORIES (US) 2007-07-04 EP disclosed
EP-1697303-A1 CATALYTIC HYDROGENATION OF NITRILES TO PRODUCE CAPSAICINOID DERIVATIVES AND AMINE COMPOUNDS, AND METHODS FOR PURIFIYING AND OBTAINING THE POLYMORPHS THEREOF STIEFEL LABORATORIES, INC. (US) 2006-09-06 EP disclosed
US-20060047171-A1 Catalytic hydrogenation of nitriles to produce capsaicinoid derivatives and amine compounds, and methods for purifying and obtaining the polymorphs thereof STIEFEL LABORATORIES, INC. 2006-03-02 US disclosed
US-4404167-A AMINO NITRILE INHIBITORS ROZENFELD IOSIF L 1983-09-13 US disclosed
US-4235730-A DISPERSANTS TEXACO INC. (US) 1980-11-25 US disclosed
US-4184024-A Polyurethanes prepared from polyols from 2,3-morpholinediones TEXACO DEVELOPMENT CORP. (US) 1980-01-15 US disclosed
US-4118422-A Polyols from 2,3-morpholinediones TEXACO DEVELOPMENT CORP. (US) 1978-10-03 US disclosed