Morpholine

Morpholine

SCHEMBL5147041

C1COCCN1.CC(N)C1CNCCO1

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
KDM4E B2RXH2 2/20 0.39
CYP2C9 P11712 2/20 0.39
GAA P10253 1/20 0.39
SLC6A2 P23975 13/20 0.35
SLC6A4 P31645 13/20 0.35
SLC6A3 Q01959 8/20 0.35
MLNR O43193 1/20 0.33
ADRB2 P07550 1/20 0.33
CHRM2 P08172 1/20 0.33
CHRM1 P11229 1/20 0.33
CHRM3 P20309 1/20 0.33
HTR2C P28335 1/20 0.33
OPRK1 P41145 1/20 0.33
KCNH2 Q12809 1/20 0.33
ALDH1A1 P00352 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
MAPK1 P28482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL185652 0.92
Ethylene Glycol SCHEMBL10850449 0.84 SLC6A2 (0.35) MEN1KMT2AKDM4ECYP2C9SLC6A2
Lactic Acid SCHEMBL4337806 0.80 SLC6A2 (0.38) MEN1KMT2AKDM4ECYP2C9SLC6A2
Propionamide SCHEMBL27586347 0.78 SLC6A2 (0.35) MEN1KMT2AKDM4ECYP2C9SLC6A2
Morpholine SCHEMBL27525337 0.77 MEN1 (0.35) MEN1KMT2AKDM4ECYP2C9GAA
SCHEMBL2314755 0.77 SLC6A2 (0.36) MEN1KMT2AKDM4ECYP2C9SLC6A2
SCHEMBL197401 0.76
SCHEMBL23929455 0.76
SCHEMBL516648 0.76
SCHEMBL12206943 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1770109-B1 Process of preparing polyamine-epihalohydrin resins with reduced byproduct content HERCULES INC (US) 2012-08-08 EP disclosed
US-20070137821-A1 Reduced byproduct polyamine-epihalohydrin resins HERCULES INCORPORATED 2007-06-21 US disclosed
EP-1777247-A2 Reduced byproduct polyamidoamine-epihalohydrin resins HERCULES INCORPORATED (US) 2007-04-25 EP disclosed
EP-1770109-A2 Process of preparing polyamine-epihalohydrin resins with reduced byproduct content HERCULES INCORPORATED (US) 2007-04-04 EP disclosed
EP-1770110-A2 Process of preparing polyamine-epihalohydrin resins with reduced byproduct content HERCULES INCORPORATED (US) 2007-04-04 EP disclosed
EP-1189972-B1 PROCESS FOR PREPARING REDUCED BYPRODUCT POLYAMINE-EPIHALOHYDRIN RESINS HERCULES INC (US) 2007-03-21 EP disclosed
US-7175740-B2 Reduced by product polyamine-epihalohydrin resins HERCULES INCORPORATED (US) 2007-02-13 US disclosed
US-20050006042-A1 Reduced by product polyamine-epihalohydrin resins HERCULES INCORPORATED 2005-01-13 US disclosed
US-20030205345-A1 Reduced by product polyamine-epihalohydrin resins SOLENIS TECHNOLOGIES, L.P. 2003-11-06 US disclosed
US-6554961-B1 Treating the resin with an acid to reduce the formation of 3-chloropropanediol wherein the pH during treatment is about 1.1 or less to make it gelation storage stable; possible enzymatic pretreatment HERCULES INCORPORATED 2003-04-29 US disclosed
US-5994488-A POLYMER COMPRISING UNITS DERIVED FROM AN ETHYLENICALLY UNSATURATED MONOMER HAVING A CHAIN CONTAINING AMINO AND ORGANOSILOXANE GROUPS TORAY INDUSTRIES, INC. (JP) 1999-11-30 US disclosed