Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22769287 | 0.79 | DPP4 (0.45) | DPP4 | |
| SCHEMBL5146975 | 0.77 | HDAC8 (0.37) | DPP4 | |
| SCHEMBL361289 | 0.75 | DPP4 (0.32) | DPP4 | |
| SCHEMBL4915211 | 0.71 | — | — | |
| SCHEMBL28176135 | 0.69 | ACACB (0.39) | — | |
| SCHEMBL3685554 | 0.69 | KCNH2 (0.36) | — | |
| SCHEMBL3180472 | 0.69 | KCNH2 (0.36) | — | |
| SCHEMBL14849717 | 0.69 | DPP4 (0.35) | DPP4 | |
| SCHEMBL1173602 | 0.69 | PRMT6 (0.33) | — | |
| SCHEMBL5432901 | 0.69 | PRMT6 (0.47) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562588-A4 | USE OF PDE4 INHIBITORS AS ADJUNCT THERAPY FOR PSYCHIATRIC DISORDERS | MERCK & CO INC (US) | 2007-10-31 | — | — | EP | disclosed |
| EP-1562588-A2 | USE OF PDE4 INHIBITORS AS ADJUNCT THERAPY FOR PSYCHIATRIC DISORDERS | Merck & Co., Inc. (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-1436290-A1 | ALKYNE-ARYL-NAPHTHYRIDIN-4(1H)-0NE DERIVATIVES AS TYPE IV PHOSPHODIESTERASE INHIBITOR | Merck Frosst Canada & Co. (CA) | 2004-07-14 | — | — | EP | disclosed |
| WO-2004045508-A2 | USE OF PDE4 INHIBITORS AS ADJUNCT THERAPY FOR PSYCHIATRIC DISORDERS | MERCK & CO., INC. (US) | 2004-06-03 | — | — | WO | disclosed |
| WO-2003018579-A1 | ALKYNE-ARYL PHOSPHODIESTERASE-4 INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2003-03-06 | — | — | WO | disclosed |