Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2933104 | 0.90 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2HPGDMAP4K4 | |
| SCHEMBL2932035 | 0.81 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2HPGDMAP4K4 | |
| SCHEMBL14022343 | 0.75 | RAB9A (0.67) | NPC1RAB9ASMN1; SMN2HPGDMAP4K4 | |
| SCHEMBL2927267 | 0.73 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2HPGDMAP4K4 | |
| SCHEMBL2926050 | 0.72 | ATR (0.49) | NPC1RAB9ASMN1; SMN2HPGDMAP4K4 | |
| SCHEMBL2927215 | 0.72 | HPGD (0.55) | NPC1RAB9ASMN1; SMN2HPGDMAP4K4 | |
| SCHEMBL2932659 | 0.72 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2HPGDMAP4K4 | |
| SCHEMBL2931009 | 0.71 | TRPV1 (0.47) | NPC1RAB9ASMN1; SMN2HPGDMAP4K4 | |
| SCHEMBL2927844 | 0.70 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2HPGDMAP4K4 | |
| SCHEMBL2924638 | 0.70 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2HPGDMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987028-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS AURORA KINASE INHIBITORS | Transtech Pharma, Inc. (US) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007095124-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS AURORA KINASE INHIBITORS | TRANSTECH PHARMA, INC. (US) | 2007-08-23 | — | — | WO | disclosed |