Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147312 | 0.85 | IKBKB (0.42) | ALDH1A1SMN1; SMN2RAB9AKDM4EGSK3B | |
| SCHEMBL2989628 | 0.84 | ALDH1A1 (0.44) | ALDH1A1GAASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5147468 | 0.83 | SMN1; SMN2 (0.40) | ALDH1A1GAASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5147268 | 0.83 | CDK2 (0.37) | ALDH1A1SMN1; SMN2LMNACDK2CLK1 | |
| SCHEMBL5181846 | 0.83 | AKT3 (0.37) | ALDH1A1SMN1; SMN2LMNACDK2CLK1 | |
| SCHEMBL5147410 | 0.82 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2RAB9AKDM4EHPGD | |
| SCHEMBL5147395 | 0.81 | CDK2 (0.38) | ALDH1A1SMN1; SMN2KDM4EHSD17B10RAF1 | |
| SCHEMBL5147310 | 0.81 | AKT3 (0.36) | ALDH1A1SMN1; SMN2CDK2CLK1PLA2G7 | |
| SCHEMBL5179013 | 0.81 | ALDH1A1 (0.42) | ALDH1A1GAASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5147497 | 0.80 | AKT3 (0.41) | ALDH1A1GAASMN1; SMN2NPC1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |